CD117

KIT

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4U0I, 1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F, 4HVS, 4K94, 4K9E, 4PGZ, 2IUH

Identifiers

Aliases

KIT, C-Kit, CD117, PBT, SCFR, KIT proto-oncogene receptor tyrosine kinase

External IDs

MGI: 96677 HomoloGene: 187 GeneCards: KIT

Targeted by Drug

cediranib, crenolanib, linifanib, masitinib, pazopanib, semaxanib, sorafenib, sunitinib

Gene ontology
Molecular function	• stem cell factor receptor activity • kinase activity • transmembrane receptor protein tyrosine kinase activity • ATP binding • cytokine binding • protein kinase activity • signal transducer, downstream of receptor, with protein tyrosine kinase activity • metal ion binding • transferase activity • protein homodimerization activity • protease binding • protein binding • protein tyrosine kinase activity • nucleotide binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • Ras guanyl-nucleotide exchange factor activity
Cellular component	• cytoplasm • membrane • cell-cell junction • cytoplasmic side of plasma membrane • cell surface • integral component of membrane • acrosomal vesicle • external side of plasma membrane • mast cell granule • extracellular space • plasma membrane
Biological process	• melanocyte migration • hemopoiesis • myeloid progenitor cell differentiation • positive regulation of MAP kinase activity • glycosphingolipid metabolic process • positive regulation of phospholipase C activity • positive regulation of tyrosine phosphorylation of Stat5 protein • hematopoietic stem cell migration • positive regulation of tyrosine phosphorylation of Stat3 protein • stem cell population maintenance • protein phosphorylation • T cell differentiation • spermatogenesis • cell chemotaxis • developmental pigmentation • melanocyte differentiation • positive regulation of Notch signaling pathway • lamellipodium assembly • cytokine-mediated signaling pathway • transmembrane receptor protein tyrosine kinase signaling pathway • melanocyte adhesion • lymphoid progenitor cell differentiation • spermatid development • erythrocyte differentiation • negative regulation of programmed cell death • protein autophosphorylation • mast cell degranulation • inflammatory response • positive regulation of MAPK cascade • myeloid leukocyte differentiation • male gonad development • phosphorylation • positive regulation of sequence-specific DNA binding transcription factor activity • epithelial cell proliferation • stem cell differentiation • detection of mechanical stimulus involved in sensory perception of sound • activation of MAPK activity • regulation of cell shape • ovarian follicle development • ectopic germ cell programmed cell death • pigmentation • Fc receptor signaling pathway • response to radiation • mast cell cytokine production • positive regulation of JAK-STAT cascade • phosphatidylinositol-mediated signaling • positive regulation of tyrosine phosphorylation of Stat1 protein • dendritic cell cytokine production • visual learning • actin cytoskeleton reorganization • megakaryocyte development • intracellular signal transduction • somatic stem cell population maintenance • erythropoietin-mediated signaling pathway • Kit signaling pathway • positive regulation of cell migration • somatic stem cell division • mast cell chemotaxis • MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • positive regulation of pseudopodium assembly • positive regulation of gene expression • positive regulation of long-term neuronal synaptic plasticity • regulation of cell proliferation • cellular response to thyroid hormone stimulus • positive regulation of cell proliferation • embryonic hemopoiesis • regulation of developmental pigmentation • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • mast cell differentiation • digestive tract development • immature B cell differentiation • germ cell migration • signal transduction • mast cell proliferation • positive regulation of GTPase activity • positive regulation of vascular smooth muscle cell differentiation • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol phosphorylation • regulation of transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3815


16590

Ensembl


ENSG00000157404


ENSMUSG00000005672

UniProt


P10721


P05532

RefSeq (mRNA)


NM_000222 NM_001093772


NM_001122733 NM_021099

RefSeq (protein)


NP_000213 NP_001087241


NP_001116205.1 NP_066922.2 NP_001116205 NP_066922

Location (UCSC)

Chr 4: 54.66 – 54.74 Mb

Chr 5: 75.57 – 75.66 Mb

PubMed search

4U0I, 1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F, 4HVS, 4K94, 4K9E, 4PGZ, 2IUH

NM_000222
NM_001093772

NM_001122733
NM_021099

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