Masitinib

Masitinib

Clinical data
Trade names	Masivet, Kinavet
AHFS/Drugs.com	International Drug Names
ATC code	L01XE22 (WHO)
Identifiers
IUPAC name 4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)benzamide
CAS Number	790299-79-5
PubChem CID	10074640
ChemSpider	8250179
KEGG	D10229
ChEMBL	CHEMBL1908391
Chemical and physical data
Formula	C28H30N6OS
Molar mass	498.64 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(c1ccc(cc1)CN2CCN(C)CC2)Nc3cc(c(cc3)C)Nc4nc(cs4)c5cccnc5
InChI InChI=InChI=1S/C28H30N6OSc1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32) Key:WJEOLQLKVOPQFV-UHFFFAOYSA-N

Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet. It has been available in Europe since the second part of 2009. In the USA it is distributed under the name Kinavet and has been available for veterinaries since 2011.

Masitinib is being studied for several human conditions including cancers, Alzheimer, Multiple Sclerosis, , and Amyotrophic Lateral Sclerosis. It is being studied in Europe for orphan diseases.

Masitinib inhibits the receptor tyrosine kinase c-Kit which is displayed by various types of tumour. It also inhibits the platelet derived growth factor receptor (PDGFR) and fibroblast growth factor receptor (FGFR).