CCL4

CCL4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HUM, 1HUN, 1JE4, 2FFK, 2FIN, 2X6L, 3TN2, 4RAL
Identifiers
Aliases	CCL4, ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4, C-C motif chemokine ligand 4
External IDs	OMIM: 182284 MGI: 98261 HomoloGene: 48153 GeneCards: CCL4
Gene ontology Molecular function • cytokine activity • CCR5 chemokine receptor binding • CCR1 chemokine receptor binding • protein binding • identical protein binding • chemokine activity Cellular component • extracellular region • extracellular space Biological process • G-protein coupled receptor signaling pathway • movement of cell or subcellular component • positive regulation of calcium-mediated signaling • monocyte chemotaxis • positive regulation of natural killer cell chemotaxis • chemokine-mediated signaling pathway • cellular response to tumor necrosis factor • cell-cell signaling • response to virus • neutrophil chemotaxis • chemotaxis • negative regulation by host of viral transcription • establishment or maintenance of cell polarity • positive regulation of GTPase activity • cell adhesion • cellular response to interleukin-1 • immune response • positive regulation of ERK1 and ERK2 cascade • cellular response to interferon-gamma • response to toxic substance • signal transduction • positive regulation of calcium ion transport • inflammatory response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6351	20303
Ensembl	n/a	ENSMUSG00000018930
UniProt	P13236	P14097
RefSeq (mRNA)	NM_002984	NM_013652
RefSeq (protein)	NP_002975	NP_038680
Location (UCSC)	Chr 17: 36.1 – 36.11 Mb	Chr 11: 83.66 – 83.66 Mb
PubMed search

1HUM, 1HUN, 1JE4, 2FFK, 2FIN, 2X6L, 3TN2, 4RAL

6351

20303

n/a

ENSMUSG00000018930

P13236

P14097

NM_002984

NM_013652

NP_002975

NP_038680

Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene.

CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells.

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Wikipedia