Bradykinin receptor B2

BDKRB2
Identifiers
Aliases	BDKRB2, B2R, BK-2, BK2, BKR2, BRB2, bradykinin receptor B2
External IDs	MGI: 102845 HomoloGene: 519 GeneCards: BDKRB2
Targeted by Drug
Bradykinin, kallidin
Gene ontology Molecular function • G-protein coupled receptor activity • type 1 angiotensin receptor binding • signal transducer activity • protease binding • protein binding • protein heterodimerization activity • phosphatidylinositol phospholipase C activity • bradykinin receptor activity Cellular component • integral component of membrane • endosome • membrane • integral component of plasma membrane • plasma membrane Biological process • G-protein coupled receptor signaling pathway • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • response to salt stress • vasoconstriction • transmembrane receptor protein tyrosine kinase signaling pathway • response to stress • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator • vasodilation • blood circulation • cell surface receptor signaling pathway • regulation of vascular permeability • regulation of vasoconstriction • negative regulation of peptidyl-serine phosphorylation • inflammatory response • arachidonic acid secretion • signal transduction • smooth muscle contraction • positive regulation of cytosolic calcium ion concentration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	624	12062
Ensembl	ENSG00000168398	ENSMUSG00000021070
UniProt	P30411	P32299
RefSeq (mRNA)	NM_000623	NM_009747
RefSeq (protein)	NP_000614	NP_033877.3 NP_033877
Location (UCSC)	Chr 14: 96.2 – 96.24 Mb	Chr 12: 105.56 – 105.59 Mb
PubMed search

624

12062

ENSG00000168398

ENSMUSG00000021070

P30411

P32299

NM_000623

NM_009747

NP_000614

NP_033877.3
NP_033877

Bradykinin receptor B₂ is a G-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans.

The B₂ receptor is a G protein-coupled receptor, probably coupled to G_q and G_i. G_q stimulates phospholipase C to increase intracellular free calcium and G_i inhibits adenylate cyclase. Furthermore, the receptor stimulates the mitogen-activated protein kinase pathways. It is ubiquitously and constitutively expressed in healthy tissues.

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Wikipedia