Amphiregulin

AREG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RNL
Identifiers
Aliases	AREG, AR, AREGB, CRDGF, SDGF, amphiregulin
External IDs	MGI: 88068 HomoloGene: 1252 GeneCards: AREG
Gene ontology Molecular function • cytokine activity • epidermal growth factor receptor binding • protein binding • growth factor activity Cellular component • cytoplasm • integral component of membrane • endoplasmic reticulum membrane • membrane • intracellular • cell surface • ER to Golgi transport vesicle membrane • endoplasmic reticulum-Golgi intermediate compartment membrane • nucleus • Golgi membrane • extracellular space Biological process • dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis • G-protein coupled receptor signaling pathway • response to estradiol • epidermal growth factor receptor signaling pathway • response to organic cyclic compound • cell-cell signaling • mammary gland branching involved in thelarche • response to peptide hormone • response to glucocorticoid • mammary gland alveolus development • negative regulation of osteoblast differentiation • positive regulation of DNA replication • ER to Golgi vesicle-mediated transport • epithelial cell proliferation involved in mammary gland duct elongation • COPII vesicle coating • positive regulation of cell proliferation • glial cell proliferation • response to cAMP • positive regulation of phosphorylation • cell proliferation • neuron projection development • response to hydrogen peroxide • positive regulation of peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	374	11839
Ensembl	ENSG00000109321	ENSMUSG00000029378
UniProt	P15514	P31955
RefSeq (mRNA)	NM_001657	NM_009704
RefSeq (protein)	NP_001648	NP_033834.1 NP_033834
Location (UCSC)	Chr 4: 74.45 – 74.46 Mb	Chr 5: 91.14 – 91.15 Mb
PubMed search

2RNL

374

11839

ENSG00000109321

ENSMUSG00000029378

P15514

P31955

NM_001657

NM_009704

NP_001648

NP_033834.1
NP_033834

Amphiregulin, also known as AREG, is a protein that in humans is encoded by the AREG gene.

The protein encoded by this gene is a member of the epidermal growth factor (EGF) family.

It is an growth factor as well as a mitogen for astrocytes, Schwann cells, fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the Epidermal growth factor receptor (EGFR) to promote the growth of normal epithelial cells.

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