Epidermal growth factor

EGF

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1IVO, 1JL9, 1NQL, 1P9J, 2KV4, 3NJP

Identifiers

Aliases

EGF, HOMG4, URG, epidermal growth factor, Epidermal growth factor

External IDs

OMIM: 131530 MGI: 95290 HomoloGene: 1483 GeneCards: EGF

Gene ontology
Molecular function	• calcium ion binding • transmembrane receptor protein tyrosine kinase activator activity • epidermal growth factor receptor binding • Wnt-protein binding • protein binding • growth factor activity • Wnt-activated receptor activity • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Cellular component	• integral component of membrane • membrane • receptor complex • extracellular region • lysosomal membrane • extracellular exosome • platelet alpha granule lumen • extracellular space • clathrin-coated vesicle membrane • plasma membrane
Biological process	• negative regulation of epidermal growth factor receptor signaling pathway • positive regulation of MAP kinase activity • epidermal growth factor receptor signaling pathway • regulation of protein localization to cell surface • positive regulation of catenin import into nucleus • ERK1 and ERK2 cascade • platelet degranulation • regulation of calcium ion import • mammary gland alveolus development • MAPK cascade • STAT protein import into nucleus • DNA replication • positive regulation of transcription, DNA-templated • activation of MAPK activity • negative regulation of secretion • positive regulation of hyaluronan biosynthetic process • positive regulation of peptidyl-threonine phosphorylation • positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process • angiogenesis • Wnt signaling pathway involved in dorsal/ventral axis specification • positive regulation of cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of cerebellar granule cell precursor proliferation • canonical Wnt signaling pathway • negative regulation of cholesterol efflux • peptidyl-tyrosine phosphorylation • positive regulation of DNA binding • positive regulation of phosphorylation • positive regulation of mitotic nuclear division • branching morphogenesis of an epithelial tube • phosphatidylinositol-mediated signaling • signal transduction • regulation of peptidyl-tyrosine phosphorylation • positive regulation of GTPase activity • ERBB2 signaling pathway • phosphatidylinositol phosphorylation • positive regulation of protein tyrosine kinase activity • regulation of phosphatidylinositol 3-kinase signaling • activation of transmembrane receptor protein tyrosine kinase activity • regulation of cell motility • activation of MAPKK activity • positive regulation of receptor internalization • positive regulation of epidermal growth factor-activated receptor activity • membrane organization • negative regulation of ERBB signaling pathway • embryonic retina morphogenesis in camera-type eye
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1950


13645

Ensembl


ENSG00000138798


ENSMUSG00000028017

UniProt


P01133


P01132

RefSeq (mRNA)


NM_001178130 NM_001178131 NM_001963


NM_010113 NM_001310737 NM_001329594

RefSeq (protein)


NP_001171601 NP_001171602 NP_001954


NP_034243.2 NP_001297666 NP_001316523 NP_034243

Location (UCSC)

Chr 4: 109.91 – 110.01 Mb

Chr 3: 129.68 – 129.76 Mb

PubMed search

1IVO, 1JL9, 1NQL, 1P9J, 2KV4, 3NJP

NM_001178130
NM_001178131
NM_001963

NM_010113
NM_001310737
NM_001329594

NP_001171601
NP_001171602
NP_001954

NP_034243.2
NP_001297666
NP_001316523
NP_034243

...
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