Alpha-enolase

ENO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PSN, 3B97
Identifiers
Aliases	ENO1, ENO1L1, MPB1, NNE, PPH, HEL-S-17, enolase 1
External IDs	OMIM: 172430 MGI: 95393 HomoloGene: 134343 GeneCards: ENO1
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.23 Start 8,861,002 bp End 8,879,249 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 E2|4 81.24 cM Start 150,236,721 bp End 150,248,879 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • metal ion binding • protein binding • lyase activity • GTPase binding • magnesium ion binding • RNA binding • cadherin binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • phosphopyruvate hydratase activity • protein homodimerization activity • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Cellular component • cytoplasm • M band • membrane • extracellular exosome • cell nucleus • extracellular space • phosphopyruvate hydratase complex • cytosol • plasma membrane • cell surface • cell cortex region Biological process • gluconeogenesis • regulation of transcription, DNA-templated • glycolytic process • response to virus • transcription, DNA-templated • negative regulation of cell growth • negative regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • positive regulation of plasminogen activation • positive regulation of muscle contraction • canonical glycolysis • negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway • positive regulation of ATP biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2023	13806
Ensembl	ENSG00000074800	ENSMUSG00000063524
UniProt	P06733	P17182
RefSeq (mRNA)	NM_001201483 NM_001428 NM_001353346	NM_023119
RefSeq (protein)	NP_001188412 NP_001419 NP_001340275	NP_075608 NP_001020559
Location (UCSC)	Chr 1: 8.86 – 8.88 Mb	Chr 4: 150.24 – 150.25 Mb
PubMed search

2PSN, 3B97

2023

13806

ENSG00000074800

ENSMUSG00000063524

P06733

P17182

NM_001201483
NM_001428
NM_001353346

NM_023119

NP_001188412
NP_001419
NP_001340275

NP_075608
NP_001020559

Enolase 1 (ENO1), more commonly known as alpha-enolase, is a glycolytic enzyme expressed in most tissues, one of the isozymes of enolase. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase, in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results in a shorter isoform that has been shown to bind to the c-myc promoter and function as a tumor suppressor. Several pseudogenes have been identified, including one on the long arm of chromosome 1. Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy.

...
Wikipedia