C-myc

MYC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A93, 1EE4, 1MV0, 1NKP, 2A93, 2OR9, 4Y7R
Identifiers
Aliases	MYC, MRTL, MYCC, bHLHe39, c-Myc, v-myc avian myelocytomatosis viral oncogene homolog
External IDs	MGI: 97250 HomoloGene: 31092 GeneCards: MYC
Gene ontology Molecular function • DNA binding • protein dimerization activity • transcription factor activity, sequence-specific DNA binding • protein complex binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • E-box binding • protein binding • repressing transcription factor binding Cellular component • cytosol • nucleoplasm • protein complex • nucleolus • nucleus Biological process • Notch signaling pathway • chromatin remodeling • negative regulation of monocyte differentiation • positive regulation of metanephric cap mesenchymal cell proliferation • regulation of transcription, DNA-templated • regulation of telomere maintenance • positive regulation of epithelial cell proliferation • positive regulation of fibroblast proliferation • cellular response to UV • oxygen transport • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • chromosome organization • MAPK cascade • cellular response to DNA damage stimulus • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • branching involved in ureteric bud morphogenesis • cellular response to drug • negative regulation of cell division • fibroblast apoptotic process • positive regulation of mesenchymal cell proliferation • cell cycle arrest • positive regulation of response to DNA damage stimulus • positive regulation of cell proliferation • positive regulation of DNA biosynthetic process • regulation of gene expression • canonical Wnt signaling pathway • negative regulation of stress-activated MAPK cascade • energy reserve metabolic process • response to growth factor • response to gamma radiation • negative regulation of fibroblast proliferation • response to drug • positive regulation of transcription from RNA polymerase II promoter • cellular iron ion homeostasis • beta-catenin-TCF complex assembly • transcription, DNA-templated • transcription from RNA polymerase II promoter • G1/S transition of mitotic cell cycle • regulation of transcription from RNA polymerase II promoter • protein deubiquitination • positive regulation of transcription, DNA-templated • positive regulation of telomerase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4609	17869
Ensembl	ENSG00000136997	ENSMUSG00000022346
UniProt	P01106	P01108
RefSeq (mRNA)	NM_002467	NM_001177352 NM_001177353 NM_001177354 NM_010849
RefSeq (protein)	NP_002458	NP_001170823.1 NP_001170824.1 NP_001170825.1 NP_001170823 NP_001170824 NP_001170825 NP_034979
Location (UCSC)	Chr 8: 127.74 – 127.74 Mb	Chr 15: 61.99 – 61.99 Mb
PubMed search

1A93, 1EE4, 1MV0, 1NKP, 2A93, 2OR9, 4Y7R

4609

17869

ENSG00000136997

ENSMUSG00000022346

P01106

P01108

NM_002467

NM_001177352
NM_001177353
NM_001177354
NM_010849

NP_002458

NP_001170825
NP_034979

Myc (c-Myc) is a regulator gene that codes for a transcription factor. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation.

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