*** Welcome to piglix ***

Alpha-1B adrenergic receptor

ADRA1B
Identifiers
Aliases ADRA1B, ADRA1, ALPHA1BAR, adrenoceptor alpha 1B
External IDs MGI: 104774 HomoloGene: 55477 GeneCards: ADRA1B
Targeted by Drug
epinephrine, methoxamine, norepinephrine, oxymetazoline, phenylephrine, alfuzosin, bmy-7378 free base, clozapine, cyproheptadine, doxazosin, indoramin, ketanserin, L-765314, mianserin, NAN 190, phentolamine, risperidone, ritanserin, silodosin, spiroxatrine, terazosin, WB-4101, prazosin, spiperone, tamsulosin
RNA expression pattern
PBB GE ADRA1B 207589 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000679

NM_001284380
NM_001284381
NM_007416

RefSeq (protein)

NP_000670

n/a

Location (UCSC) Chr 5: 159.92 – 159.97 Mb Chr 11: 43.77 – 43.9 Mb
PubMed search

NM_000679

NM_001284380
NM_001284381
NM_007416

NP_000670

n/a

The alpha-1B adrenergic receptor1B adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.

There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.

Alpha-1B adrenergic receptor has been shown to interact with AP2M1. A role in regulation of dopaminergic neurotransmission has also been suggested.


...
Wikipedia

...