Adenosine A2a receptor

ADORA2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YDO, 2YDV, 3EML, 3PWH, 3QAK, 3REY, 3RFM, 3UZA, 3UZC, 3VG9, 3VGA, 4EIY, 4UG2, 4UHR, 5IU4, 5IU7, 5IUA, 5IU8, 5IUB
Identifiers
Aliases	ADORA2A, adenosine A2a receptor, A2aR, ADORA2, RDC8
External IDs	MGI: 99402 HomoloGene: 20166 GeneCards: ADORA2A
Targeted by Drug
adenosine, BAY 60-6583, regadenoson anhydrous, uk-432097, CCPA, cgs-21680, cyclopentyladenosine, caffeine, CGS 15943, 8-cyclopentyl-1,3-dipropylxanthine, , galangin, istradefylline, morin, preladenant, rolofylline, sakuranetin, sch-442416, sch-58261, theophylline anhydrous, ZM-241385
Gene ontology Molecular function • G-protein coupled adenosine receptor activity • G-protein coupled receptor activity • signal transducer activity • protein binding • identical protein binding • enzyme binding • type 5 metabotropic glutamate receptor binding • protein heterodimerization activity • alpha-actinin binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • intermediate filament • endomembrane system • postsynaptic density • axon • dendrite • axolemma • asymmetric synapse • presynaptic membrane • neuronal cell body • postsynaptic membrane • presynaptic active zone Biological process • cAMP biosynthetic process • cellular protein metabolic process • G-protein coupled receptor signaling pathway • adenosine receptor signaling pathway • sensory perception • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • cell-cell signaling • blood coagulation • blood circulation • cellular defense response • central nervous system development • phagocytosis • inflammatory response • signal transduction • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway • apoptotic process • synaptic transmission, dopaminergic • response to amphetamine • regulation of transcription, DNA-templated • negative regulation of protein kinase activity • adenylate cyclase-activating G-protein coupled receptor signaling pathway • protein kinase C-activating G-protein coupled receptor signaling pathway • synaptic transmission, cholinergic • locomotory behavior • negative regulation of cell proliferation • positive regulation of glutamate secretion • positive regulation of acetylcholine secretion, neurotransmission • regulation of norepinephrine secretion • positive regulation of cAMP biosynthetic process • response to caffeine • positive regulation of synaptic transmission, GABAergic • synaptic transmission, glutamatergic • positive regulation of urine volume • positive regulation of renal sodium excretion • negative regulation of locomotion • vasodilation • response to drug • eating behavior • negative regulation of vascular permeability • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • response to alkaloid • negative regulation of neuron apoptotic process • positive regulation of circadian sleep/wake cycle, sleep • negative regulation of alpha-beta T cell activation • astrocyte activation • regulation of synaptic plasticity • neuron projection morphogenesis • positive regulation of protein secretion • negative regulation of inflammatory response • regulation of mitochondrial membrane potential • membrane depolarization • regulation of calcium ion transport • positive regulation of synaptic transmission, glutamatergic • excitatory postsynaptic potential • inhibitory postsynaptic potential • prepulse inhibition • positive regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	135	11540
Ensembl	ENSG00000128271	ENSMUSG00000020178
UniProt	P29274	Q60613
RefSeq (mRNA)	NM_000675 NM_001278497 NM_001278498 NM_001278499 NM_001278500	NM_009630 NM_001331095 NM_001331096
RefSeq (protein)	NP_000666 NP_001265426 NP_001265427 NP_001265428 NP_001265429	NP_033760.2 NP_001318024 NP_001318025 NP_033760
Location (UCSC)	Chr 22: 24.42 – 24.44 Mb	Chr 10: 75.32 – 75.33 Mb
PubMed search

2YDO, 2YDV, 3EML, 3PWH, 3QAK, 3REY, 3RFM, 3UZA, 3UZC, 3VG9, 3VGA, 4EIY, 4UG2, 4UHR, 5IU4, 5IU7, 5IUA, 5IU8, 5IUB

135

11540

ENSG00000128271

ENSMUSG00000020178

P29274

...
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