SCH-58261

SCH-58261
Clinical data

ATC code	none
Legal status
Legal status	Uncontrolled
Identifiers
IUPAC name 5-Amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine
CAS Number	160098-96-4^N
PubChem CID	176408
IUPHAR/BPS	403
ChemSpider	153647^Y
ChEMBL	CHEMBL17127^Y
Chemical and physical data
Formula	C₁₈H₁₅N₇O
Molar mass	345.357 g/mol
3D model (Jmol)	Interactive image
SMILES c1ccccc1CCN1N=CC2=C1N=C(N)N3C2=NC(C4=CC=CO4)=N3
InChI InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)^Y Key:UTLPKQYUXOEJIL-UHFFFAOYSA-N^Y
^NY (what is this?)

SCH-58261 is a drug which acts as a potent and selective antagonist for the adenosine receptor A_2A, with more than 50x selectivity for A_2A over other adenosine receptors. It has been used to investigate the mechanism of action of caffeine, which is a mixed A₁ / A_2A antagonist, and has shown that the A_2A receptor is primarily responsible for the stimulant effects of caffeine, but blockade of both A₁ and A_2A receptors is required to accurately replicate caffeine's effects in animals. SCH-58261 has also shown antidepressant and neuroprotective effects in a variety of animal models, and has been investigated as a possible treatment for Parkinson's disease.

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