ZM-241,385

ZM-241,385

Names
IUPAC name 4-(2-(7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-ylamino)ethyl)phenol
Identifiers
CAS Number	139180-30-6 Y
3D model (Jmol)	Interactive image
ChEMBL	ChEMBL113142 N
ChemSpider	153646 N
ECHA InfoCard	100.216.533
IUPHAR/BPS	405
PubChem	176407
InChI InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22) N Key: PWTBZOIUWZOPFT-UHFFFAOYSA-N N InChI=1/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22) Key: PWTBZOIUWZOPFT-UHFFFAOYAJ
SMILES Oc1ccc(CCNc2nc3nc(c4ccco4)nn3c(N)n2)cc1
Properties
Chemical formula	C16H15N7O2
Molar mass	337.34 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N  (what is YN ?)
Infobox references

ZM-241,385 is a high affinity antagonist ligand selective for the adenosine A_2A receptor.

In animal models, ZM-241,385 has been shown to protect against beta amyloid neurotoxicity and therefore may be useful as a treatment for Alzheimer's disease. ZM-241,385 has also been shown to enhance L-DOPA derived dopamine release and therefore may be useful in the treatment of Parkinson's disease.

ZM 241385 at the US National Library of Medicine Medical Subject Headings (MeSH)