AXIN2

AXIN2
Identifiers
Aliases	AXIN2, AXIL, ODCRCS, axin 2
External IDs	MGI: 1270862 HomoloGene: 3420 GeneCards: AXIN2
Gene ontology Molecular function • I-SMAD binding • GTPase activator activity • protein binding • enzyme binding • ubiquitin protein ligase binding • beta-catenin binding Cellular component • cytoplasm • cytosol • centrosome • plasma membrane • nucleus • beta-catenin destruction complex Biological process • regulation of mismatch repair • intramembranous ossification • somitogenesis • bone mineralization • positive regulation of protein phosphorylation • positive regulation of cell death • regulation of centromeric sister chromatid cohesion • positive regulation of canonical Wnt signaling pathway • positive regulation of epithelial to mesenchymal transition • negative regulation of osteoblast differentiation • odontogenesis • multicellular organism development • cellular protein localization • mRNA stabilization • maintenance of DNA repeat elements • regulation of Wnt signaling pathway • negative regulation of catenin import into nucleus • chondrocyte differentiation involved in endochondral bone morphogenesis • regulation of chondrocyte development • secondary heart field specification • cell proliferation • negative regulation of canonical Wnt signaling pathway • negative regulation of cell proliferation • positive regulation of GTPase activity • beta-catenin-TCF complex assembly • Wnt signaling pathway • protein deubiquitination Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8313	12006
Ensembl	ENSG00000168646	ENSMUSG00000000142
UniProt	Q9Y2T1	O88566
RefSeq (mRNA)	NM_004655	NM_015732
RefSeq (protein)	NP_004646	NP_056547.3 NP_056547
Location (UCSC)	Chr 17: 65.53 – 65.56 Mb	Chr 11: 108.92 – 108.95 Mb
PubMed search

8313

12006

ENSG00000168646

ENSMUSG00000000142

Q9Y2T1

O88566

NM_004655

NM_015732

NP_004646

NP_056547.3
NP_056547

Axin-2 also known as axin-like protein (Axil) or axis inhibition protein 2 (AXIN2) or conductin is a protein that in humans is encoded by the AXIN2 gene.

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin.

The deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

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Wikipedia