Adenomatous polyposis coli

APC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DEB, 1EMU, 1JPP, 1M5I, 1T08, 1TH1, 1V18, 2RQU, 3AU3, 3NMW, 3NMX, 3NMZ, 3QHE, 3RL7, 3RL8, 3T7U, 4G69, 4YJL, 4YK6, 4YJE
Identifiers
Aliases	APC, BTPS2, DP2, DP2.5, DP3, GS, PPP1R46, adenomatous polyposis coli, WNT signaling pathway regulator
External IDs	MGI: 88039 HomoloGene: 30950 GeneCards: APC
Gene ontology Molecular function • gamma-catenin binding • protein kinase binding • microtubule plus-end binding • microtubule binding • cadherin binding • protein kinase regulator activity • protein binding • beta-catenin binding • ubiquitin protein ligase binding Cellular component • cytoskeleton • adherens junction • beta-catenin destruction complex • nucleoplasm • cytoplasm • cell projection • cytosol • catenin complex • cell junction • nucleus • lamellipodium • membrane • Wnt signalosome • centrosome • cell-cell adherens junction • microtubule • kinetochore • bicellular tight junction • ruffle membrane • plasma membrane • lateral plasma membrane • perinuclear region of cytoplasm Biological process • negative regulation of cell proliferation • negative regulation of cyclin-dependent protein serine/threonine kinase activity • mitotic spindle assembly checkpoint • positive regulation of cell migration • positive regulation of protein catabolic process • bicellular tight junction assembly • regulation of microtubule-based process • cell cycle arrest • positive regulation of pseudopodium assembly • regulation of attachment of spindle microtubules to kinetochore • cellular response to DNA damage stimulus • protein complex assembly • negative regulation of Wnt signaling pathway • cell adhesion • mitotic cytokinesis • negative regulation of microtubule depolymerization • positive regulation of apoptotic process • canonical Wnt signaling pathway • cell migration • proteasome-mediated ubiquitin-dependent protein catabolic process • beta-catenin destruction complex assembly • beta-catenin destruction complex disassembly • negative regulation of canonical Wnt signaling pathway • Wnt signaling pathway • protein deubiquitination • execution phase of apoptosis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	324	11789
Ensembl	ENSG00000134982	ENSMUSG00000005871
UniProt	P25054	Q61315
RefSeq (mRNA)	NM_001127511 NM_000038 NM_001127510	NM_007462
RefSeq (protein)	NP_000029 NP_001120982 NP_001120983	n/a
Location (UCSC)	Chr 5: 112.71 – 112.85 Mb	Chr 18: 34.22 – 34.32 Mb
PubMed search

1DEB, 1EMU, 1JPP, 1M5I, 1T08, 1TH1, 1V18, 2RQU, 3AU3, 3NMW, 3NMX, 3NMZ, 3QHE, 3RL7, 3RL8, 3T7U, 4G69, 4YJL, 4YK6, 4YJE

324

11789

ENSG00000134982

ENSMUSG00000005871

...
Wikipedia