GSK3B

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes

1GNG, 1H8F, 1I09, 1J1B, 1J1C, 1O6K, 1O6L, 1O9U, 1PYX, 1Q3D, 1Q3W, 1Q41, 1Q4L, 1Q5K, 1R0E, 1UV5, 2JDO, 2JDR, 2JLD, 2O5K, 2OW3, 2UW9, 2X39, 2XH5, 3CQU, 3CQW, 3DU8, 3E87, 3E88, 3E8D, 3F7Z, 3F88, 3GB2, 3I4B, 3L1S, 3M1S, 3MV5, 3OW4, 3PUP, 3Q3B, 3QKK, 3SAY, 3SD0, 3ZDI, 3ZRK, 3ZRL, 3ZRM, 4ACC, 4ACD, 4ACG, 4ACH, 4AFJ, 4B7T, 4DIT, 4EKK, 4IQ6, 4J1R, 4J71, 4NM0, 4NM3, 4NM5, 4NM7, 4PTC, 4PTE, 4PTG, 5F94, 5F95, 5HLP, 5HLN

Identifiers

Aliases

GSK3B, Gsk3b, 7330414F15Rik, 8430431H08Rik, C86142, GSK-3, GSK-3beta, GSK3

External IDs

MGI: 1861437 HomoloGene: 55629 GeneCards: GSK3B

EC number

2.7.11.1

Targeted by Drug

tideglusib

Gene ontology
Molecular function	• kinase activity • ATP binding • protein kinase activity • protein kinase A catalytic subunit binding • protein serine/threonine kinase activity • transferase activity • beta-catenin binding • RNA polymerase II transcription factor binding • NF-kappaB binding • tau-protein kinase activity • protein binding • protein kinase binding • nucleotide binding • p53 binding • ubiquitin protein ligase binding • protease binding
Cellular component	• cytoplasm • cytosol • membrane • mitochondrion • perinuclear region of cytoplasm • nucleus • centrosome • dendritic shaft • membrane-bounded organelle • Wnt signalosome • growth cone • plasma membrane • neuronal cell body • beta-catenin destruction complex • cell body • intracellular ribonucleoprotein complex • postsynaptic density
Biological process	• myotube differentiation • regulation of neuron projection development • negative regulation of cardiac muscle hypertrophy • rhythmic process • negative regulation of type B pancreatic cell development • negative regulation of protein binding • negative regulation of glycogen (starch) synthase activity • circadian rhythm • animal organ morphogenesis • glycogen metabolic process • superior temporal gyrus development • negative regulation of canonical Wnt signaling pathway • hypermethylation of CpG island • regulation of gene expression by genetic imprinting • chemical synaptic transmission, postsynaptic • negative regulation of protein complex assembly • positive regulation of peptidyl-serine phosphorylation • ER overload response • positive regulation of protein export from nucleus • positive regulation of GTPase activity • protein export from nucleus • protein autophosphorylation • cellular response to interleukin-3 • positive regulation of axon extension • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • cell differentiation • negative regulation of protein localization to nucleus • negative regulation of neuron projection development • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway • phosphorylation • carbohydrate metabolic process • positive regulation of cell-matrix adhesion • cellular response to hepatocyte growth factor stimulus • canonical Wnt signaling pathway involved in positive regulation of apoptotic process • positive regulation of stem cell differentiation • negative regulation of apoptotic process • nervous system development • dopamine receptor signaling pathway • regulation of microtubule-based process • epithelial to mesenchymal transition • positive regulation of protein binding • myoblast fusion • peptidyl-threonine phosphorylation • fat cell differentiation • positive regulation of protein complex assembly • axonogenesis • re-entry into mitotic cell cycle • positive regulation of neuron death • negative regulation of glycogen biosynthetic process • multicellular organism development • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • negative regulation of NFAT protein import into nucleus • protein localization to microtubule • positive regulation of peptidyl-threonine phosphorylation • peptidyl-serine phosphorylation • extrinsic apoptotic signaling pathway in absence of ligand • regulation of cellular response to heat • negative regulation of signal transduction • negative regulation of neuron maturation • cell migration • hippocampus development • positive regulation of transcription from RNA polymerase II promoter • beta-catenin destruction complex disassembly • proteasome-mediated ubiquitin-dependent protein catabolic process • Wnt signaling pathway • beta-catenin destruction complex assembly • protein phosphorylation • positive regulation of gene expression • positive regulation of mitochondrion organization • intracellular signal transduction • positive regulation of protein catabolic process • canonical Wnt signaling pathway • negative regulation of dopaminergic neuron differentiation • positive regulation of cardiac muscle cell differentiation • positive regulation of autophagy • negative regulation of TOR signaling
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2932


56637

Ensembl


ENSG00000082701


ENSMUSG00000022812

UniProt


P49841


Q9WV60

RefSeq (mRNA)


NM_001146156 NM_002093


NM_019827 NM_001347232

RefSeq (protein)


NP_001139628 NP_002084


NP_062801.1 NP_001334161 NP_062801

Location (UCSC)

Chr 3: 119.82 – 120.09 Mb

Chr 16: 38.09 – 38.25 Mb

PubMed search

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