AT1 receptor

AGTR1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4YAY, 4ZUD

Identifiers

Aliases

AGTR1, AG2S, AGTR1B, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R, angiotensin II receptor type 1

External IDs

OMIM: 106165 MGI: 87964 HomoloGene: 3556 GeneCards: AGTR1

Targeted by Drug

candesartan, eprosartan, irbesartan, losartan, tasosartan, telmisartan, valsartan

Gene ontology
Molecular function	• G-protein coupled receptor activity • angiotensin type II receptor activity • angiotensin type I receptor activity • signal transducer activity • bradykinin receptor binding • protein binding • protein heterodimerization activity
Cellular component	• integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • intracellular
Biological process	• G-protein coupled receptor signaling pathway • positive regulation of cellular protein metabolic process • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • positive regulation of inflammatory response • regulation of blood vessel diameter by renin-angiotensin • positive regulation of phospholipase A2 activity • regulation of renal sodium excretion • kidney development • positive regulation of cholesterol esterification • phospholipase C-activating angiotensin-activated signaling pathway • positive regulation of cytosolic calcium ion concentration • angiotensin-activated signaling pathway • renin-angiotensin regulation of aldosterone production • phospholipase C-activating G-protein coupled receptor signaling pathway • positive regulation of macrophage derived foam cell differentiation • positive regulation of reactive oxygen species metabolic process • regulation of vasoconstriction • low-density lipoprotein particle remodeling • regulation of cell proliferation • regulation of cell growth • Rho protein signal transduction • positive regulation of NAD(P)H oxidase activity • regulation of inflammatory response • cell chemotaxis • regulation of systemic arterial blood pressure by renin-angiotensin • calcium-mediated signaling • signal transduction • regulation of blood vessel diameter
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


185


11607

Ensembl


ENSG00000144891


ENSMUSG00000049115

UniProt


P30556


P29754

RefSeq (mRNA)


NM_032049 NM_000685 NM_004835 NM_009585 NM_031850


NM_177322

RefSeq (protein)


NP_000676 NP_004826 NP_033611 NP_114038 NP_114438


NP_796296.1 NP_796296

Location (UCSC)

Chr 3: 148.7 – 148.74 Mb

Chr 13: 30.34 – 30.38 Mb

PubMed search

NM_032049
NM_000685
NM_004835
NM_009585
NM_031850

NM_177322

NP_000676
NP_004826
NP_033611
NP_114038
NP_114438

NP_796296.1
NP_796296

...
Wikipedia