Telmisartan

Telmisartan

Clinical data
Trade names	Micardis
AHFS/Drugs.com	Monograph
MedlinePlus	a601249
Pregnancy category	AU: D US: D (Evidence of risk)
Routes of administration	Oral
ATC code	C09CA07 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	42–100%
Protein binding	>99.5%
Metabolism	Minimal hepatic (glucuronidation)
Biological half-life	24 hours
Excretion	Faecal 97%
Identifiers
IUPAC name 2-(4-{[4-Methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}phenyl)benzoic acid
CAS Number	144701-48-4 Y
PubChem (CID)	65999
IUPHAR/BPS	592
DrugBank	DB00966 Y
ChemSpider	59391 Y
UNII	U5SYW473RQ Y
KEGG	D00627 Y
ChEBI	CHEBI:9434 Y
ChEMBL	CHEMBL1017 Y
ECHA InfoCard	100.149.347
Chemical and physical data
Formula	C33H30N4O2
Molar mass	514.617 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(O)c1ccccc1c2ccc(cc2)Cn3c4cc(cc(c4nc3CCC)C)c5nc6ccccc6n5C
InChI InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39) Y Key:RMMXLENWKUUMAY-UHFFFAOYSA-N Y

Telmisartan (INN) /tɛlmɪˈsɑːrtən/ is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension. It was discovered by Boehringer Ingelheim and launched in 1999 as Micardis.

In January 2014, Actavis as generic version of Micardis got appoval from FDA.

Telmisartan is indicated in the treatment of essential hypertension.

Telmisartan is contraindicated during pregnancy. Like other drugs affecting the renin-angiotensin system (RAS), telmisartan can cause birth defects, stillbirths, and neonatal deaths. It is not known whether the drug passes into the breast milk. Also it is contraindicated in bilateral renal artery stenosis in which it can cause renal failure.

Side effects are similar to other angiotensin II receptor antagonists and include tachycardia and bradycardia (fast or slow heartbeat), hypotension (low blood pressure), edema (swelling of arms, legs, lips, tongue, or throat, the latter leading to breathing problems), and allergic reactions.