ASIC4

Identifiers

ASIC4, ACCN4, BNAC4, acid sensing ion channel subunit family member 4

External IDs

MGI: 2652846 HomoloGene: 11166 GeneCards: ASIC4

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2q35	Start	219,514,170 bp
Band	2q35	End	219,538,772 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	1\|1 C4	Start	75,450,436 bp
Band	1\|1 C4	End	75,474,343 bp

Gene ontology
Molecular function	• ion channel activity • sodium ion transmembrane transporter activity • sodium channel activity
Cellular component	• integral component of membrane • integral component of plasma membrane • membrane
Biological process	• ion transport • sodium ion transport • ion transmembrane transport • sodium ion transmembrane transport • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


55515


241118

Ensembl


ENSG00000072182


ENSMUSG00000033007

UniProt


Q96FT7


Q7TNS7

RefSeq (mRNA)


NM_018674 NM_182847


NM_183022

RefSeq (protein)


NP_061144 NP_878267


NP_898843

Location (UCSC)

Chr 2: 219.51 – 219.54 Mb

Chr 2: 75.45 – 75.47 Mb

PubMed search

Acid-sensing ion channel 4 (ASIC4) also known as amiloride-sensitive cation channel 4 (ACCN4) is a protein that in humans is encoded by the ASIC4 gene. The ASIC4 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals. The cDNA of this gene was first cloned in 2000. The ASIC genes have splicing variants that encode different proteins that are called isoforms.

These genes are mainly expressed in the central and peripheral nervous system.

ASICs can form both homotrimeric (meaning composed of three identical subunits) and heterotrimeric channels.

This gene encodes a member of the ASIC/ENaC superfamily of proteins. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane (TM) regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The TM regions are generally symbolized as TM1 (clone to N-terminus) and TM2 (close to C-terminus).

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Wikipedia