Amiloride

Amiloride

Clinical data
Trade names	Midamor, others
AHFS/Drugs.com	Monograph
Pregnancy category	US: B (No risk in non-human studies)
Routes of administration	by mouth
ATC code	C03DB01 (WHO)
Legal status
Legal status	UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	Readily absorbed, 15–25%
Protein binding	~23%
Metabolism	Nil
Onset of action	2 hours (peak at 6–10 hours, duration ~24 hours)
Biological half-life	6 to 9 hours
Excretion	urine (20–50%), feces (40%)
Identifiers
IUPAC name 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazine-2-carboxamide
Synonyms	MK-870
CAS Number	2016-88-8 Y
PubChem CID	16231
IUPHAR/BPS	2421
DrugBank	DB00594 Y
ChemSpider	15403 Y
UNII	7M458Q65S3
KEGG	D07447 Y
ChEBI	CHEBI:2639 Y
ChEMBL	CHEMBL945 Y
ECHA InfoCard	100.018.205
Chemical and physical data
Formula	C6H8ClN7O
Molar mass	229.627 g/mol
3D model (Jmol)	Interactive image
SMILES Clc1nc(C(=O)\N=C(/N)N)c(nc1N)N
InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15) Y Key:XSDQTOBWRPYKKA-UHFFFAOYSA-N Y

Amiloride, sold under the trade name Midamor among others, is a medication typically used with other medications to treat high blood pressure or swelling due to heart failure or cirrhosis of the liver. The medication it is used with often include a thiazide or loop diuretic. It is taken by mouth. Onset of action is about two hours and it lasts for about a day.

Common side effects include high blood potassium, vomiting, loss of appetite, rash, and headache. The risk of high blood potassium is greater in those with kidney problems, diabetes, and those who are older. Amiloride is in the potassium-sparing diuretic family of medications. It works by increase the amount of sodium and decreasing the amount of potassium released by the distal tubule of the kidney.

Amiloride was developed in 1967. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. In the United States the wholesale price of a month of medication is about 20.10 USD. In the United Kingdom a month of medication costs the NHS about 24 pounds.

Amiloride is contraindicated in people with Addison's disease, hyperkalaemia, hyponatremia and anuria.

Amiloride's chemical structure contains a guanidinium group containing pyrazine derivative.