ALOX15B

ALOX15B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4NRE
Identifiers
Aliases	ALOX15B, 15-LOX-2, arachidonate 15-lipoxygenase, type B
External IDs	MGI: 1098228 HomoloGene: 886 GeneCards: ALOX15B
Gene ontology Molecular function • iron ion binding • calcium ion binding • dioxygenase activity • metal ion binding • arachidonate 8(S)-lipoxygenase activity • linoleate 13S-lipoxygenase activity • oxidoreductase activity • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • lipid binding • arachidonate 15-lipoxygenase activity Cellular component • intracellular • extracellular exosome • extrinsic component of membrane • cytosol • nucleus • membrane • cytoskeleton • plasma membrane • cytoplasm Biological process • apoptotic process • linoleic acid metabolic process • negative regulation of growth • lipid metabolic process • positive regulation of keratinocyte differentiation • positive regulation of chemokine secretion • negative regulation of cell cycle • prostate gland development • lipoxygenase pathway • hepoxilin biosynthetic process • positive regulation of macrophage derived foam cell differentiation • negative regulation of cell migration • positive regulation of peroxisome proliferator activated receptor signaling pathway • regulation of epithelial cell differentiation • oxidation-reduction process • negative regulation of cell proliferation • arachidonic acid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	247	11688
Ensembl	ENSG00000179593	ENSMUSG00000020891
UniProt	O15296	O35936
RefSeq (mRNA)	NM_001141 NM_001039130 NM_001039131	NM_009661
RefSeq (protein)	NP_001034219 NP_001034220 NP_001132	NP_033791.1 NP_033791
Location (UCSC)	Chr 17: 8.04 – 8.05 Mb	Chr 11: 69.18 – 69.2 Mb
PubMed search

4NRE

247

11688

ENSG00000179593

ENSMUSG00000020891

O15296

O35936

NM_001141
NM_001039130
NM_001039131

NM_009661

NP_001034219
NP_001034220
NP_001132

NP_033791.1
NP_033791

Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene. ALOX15B, also known as 15-lipoxygenase-2 (15-LO-2 or 15-LOX-2), is distinguished from its related oxygenase, ALOX15 or 15-lipoxygenase-1.

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. 15-LOX-2 has 38-39% amino acid sequence identity to human 15-LOX-1 and 12-lipoxygenase and 44% amino acid sequence identity to human 5-lipoxygenase. 15-LOX-2 converts arachidonic acid almost exclusively to the S stereoisomer of 15-Hydroperoxyicosatetraenoic acid which is commonly reduced to the S stereoisomer 15-Hydroxyeicosatetraenoic acid by ubiquitous cellular peroxidases; it metabolizes linoleic acid less effectively, converting this fatty acid to the S stereoisomer of 13-hydroperoxyoctadecadienoic acid which is likewise rapidly reduced to the S stereoisomer of 13-Hydroxyoctadecadienoic acid. The ALOX15B gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.

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