ALOX15

ALOX15
Identifiers
Aliases	ALOX15, 12-LOX, 15-LOX-1, 15LOX-1, arachidonate 15-lipoxygenase
External IDs	MGI: 87997 HomoloGene: 44935 GeneCards: ALOX15
Gene ontology Molecular function • hepoxilin A3 synthase activity • iron ion binding • eoxin A4 synthase activity • dioxygenase activity • hepoxilin-epoxide hydrolase activity • metal ion binding • protein binding • oxidoreductase activity • phosphatidylinositol-4,5-bisphosphate binding • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • lipid binding • arachidonate 15-lipoxygenase activity • arachidonate 12-lipoxygenase activity Cellular component • cytoplasm • cytosol • membrane • extrinsic component of cytoplasmic side of plasma membrane • lipid particle • plasma membrane Biological process • cellular response to calcium ion • bone mineralization • leukotriene metabolic process • positive regulation of heterotypic cell-cell adhesion • positive regulation of actin filament polymerization • negative regulation of adaptive immune response • ossification • lipoxin A4 biosynthetic process • lipid metabolic process • wound healing • phosphatidylethanolamine biosynthetic process • regulation of peroxisome proliferator activated receptor signaling pathway • response to endoplasmic reticulum stress • fatty acid metabolic process • apoptotic cell clearance • lipoxygenase pathway • hepoxilin biosynthetic process • regulation of engulfment of apoptotic cell • positive regulation of ERK1 and ERK2 cascade • inflammatory response • oxidation-reduction process • cellular response to interleukin-13 • positive regulation of cell-substrate adhesion • arachidonic acid metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	246	11687
Ensembl	ENSG00000161905	ENSMUSG00000018924
UniProt	P16050	P39654
RefSeq (mRNA)	NM_001140	NM_009660
RefSeq (protein)	NP_001131	NP_033790.3 NP_033790
Location (UCSC)	Chr 17: 4.63 – 4.64 Mb	Chr 11: 70.34 – 70.35 Mb
PubMed search

246

11687

ENSG00000161905

ENSMUSG00000018924

P16050

P39654

NM_001140

NM_009660

NP_001131

NP_033790.3
NP_033790

ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism of polyunsaturated fatty acids to a wide range of physiologically and pathologically important products. In humans, it is encoded by the ALOX15 gene located on chromosome 17p13.3. This 11 kilobase pair gene consists of 14 exons and 13 introns coding for a 75 kiloDalton protein composed of 662 amino acids. 15-LO is to be distinguished from another human 15-lipoxygenase enzyme, ALOX15B (also termed 15-lipoxygenase-2).Orthologs of ALOX15, termed Alox15, are widely distributed in animal and plant species but commonly have different enzyme activities and make somewhat different products than ALOX15.

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Wikipedia