12-lipoxygenase

ALOX12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3D3L
Identifiers
Aliases	ALOX12, 12-LOX, 12S-LOX, LOG12, arachidonate 12-lipoxygenase, 12S type
External IDs	MGI: 87998 HomoloGene: 560 GeneCards: ALOX12
Gene ontology Molecular function • hepoxilin A3 synthase activity • iron ion binding • arachidonate 12-lipoxygenase activity • dioxygenase activity • hepoxilin-epoxide hydrolase activity • metal ion binding • protein binding • linoleate 13S-lipoxygenase activity • oxidoreductase activity • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen • hydrolase activity Cellular component • cytoplasm • cytosol • membrane • sarcolemma • extracellular exosome Biological process • movement of cell or subcellular component • linoleic acid metabolic process • positive regulation of cell death • positive regulation of endothelial cell differentiation • establishment of skin barrier • lipoxin A4 biosynthetic process • lipid metabolic process • positive regulation of cell migration • lipoxin B4 biosynthetic process • aging • negative regulation of apoptotic process • negative regulation of platelet aggregation • negative regulation of muscle cell apoptotic process • fatty acid metabolic process • positive regulation of angiogenesis • reactive oxygen species metabolic process • superoxide anion generation • positive regulation of endothelial cell migration • lipoxygenase pathway • hepoxilin biosynthetic process • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of cell growth • positive regulation of gene expression • leukotriene A4 metabolic process • positive regulation of mitochondrial depolarization • fatty acid oxidation • positive regulation of cell proliferation • positive regulation of apoptotic process • cellular response to lipid • hepoxilin metabolic process • lipoxin metabolic process • oxidation-reduction process • positive regulation of cell adhesion • positive regulation of smooth muscle cell proliferation • arachidonic acid metabolic process • positive regulation of blood vessel diameter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	239	11684
Ensembl	ENSG00000108839	ENSMUSG00000000320
UniProt	P18054	P39655
RefSeq (mRNA)	NM_000697	NM_007440 NM_001331118
RefSeq (protein)	NP_000688	NP_031466.2 NP_001318047 NP_031466
Location (UCSC)	Chr 17: 7 – 7.01 Mb	Chr 11: 70.24 – 70.26 Mb
PubMed search

arachidonate 12-lipoxygenase
Identifiers
EC number	1.13.11.31
CAS number	82391-43-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
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PubMed	articles
NCBI	proteins

3D3L

239

11684

ENSG00000108839

ENSMUSG00000000320

P18054

P39655

NM_000697

NM_007440
NM_001331118

NP_000688

NP_031466.2
NP_001318047
NP_031466

ALOX12 (EC 1.13.11.31), also known as arachidonate 12-lipoxygenase, 12-lipoxygenase, 12S-Lipoxygenase, 12-LOX, and 12S-LOX is a lipoxygenase-type enzyme that in humans is encoded by the ALOX12 gene which is located along with other lipoyxgenases on chromosome 17p13.3. ALOX12 is 75 kilodalton protein composed of 663 amino acids.

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