"50 Ways to Leave Your Lover" is a song by the American singer-songwriter Paul Simon. It was the second single from his fourth studio album, Still Crazy After All These Years (1975), released on Columbia Records. Backing vocals on the single were performed by Patti Austin, Valerie Simpson, and Phoebe Snow. The song features a recognizable repeated drum riff performed by drummer Steve Gadd.

One of his most popular singles, "50 Ways" was released in December 1975 and began to see chart success within the new year. It became Simon's sole number-one hit on the Billboard Hot 100 in the United States, and was his highest position in France, where it peaked at number two. Elsewhere, the song was a top 20 hit in Canada and New Zealand. The single was certified gold by the Recording Industry Association of America (RIAA), denoting sales of over one million copies.

Written after Simon's divorce from first wife Peggy Harper, the song is a mistress's humorous advice to a husband on ways to end a relationship. The song was recorded in a small New York City studio on Broadway.

"50 Ways to Leave Your Lover" was Paul Simon's biggest solo hit and broke in the US in late 1975. It hit number one on the US Billboard Hot 100 on February 7, 1976 (his only number one on that chart as a solo act), and remained there for three weeks; it topped the adult contemporary chart for two weeks. Overseas, on the UK Singles Chart, the song reached number 23 in January 1976. It was certified gold on March 11, 1976, and remained a best seller for nearly five months. Billboard ranked it as the No. 8 song of 1976.

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