5α reductase type II

SRD5A2
Identifiers
Aliases	SRD5A2, entrez:6716, steroid 5 alpha-reductase 2
External IDs	OMIM: 607306 MGI: 2150380 HomoloGene: 37292 GeneCards: SRD5A2
Gene location (Human) Chr. Chromosome 2 (human) Band 2p23.1 Start 31,522,480 bp End 31,581,067 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 E2 Start 74,017,706 bp End 74,047,916 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • oxidoreductase activity, acting on the CH-CH group of donors • sterol 5-alpha reductase activity • cholestenone 5-alpha-reductase activity • amide binding • oxidoreductase activity • 3-oxo-5-alpha-steroid 4-dehydrogenase activity • testosterone dehydrogenase [NAD(P) activity] Cellular component • cytoplasm • organelle membrane • integral component of membrane • membrane • cell body fiber • intracellular membrane-bounded organelle • neuronal cell body • endoplasmic reticulum • endoplasmic reticulum membrane Biological process • cell differentiation • male gonad development • phthalate metabolic process • biphenyl metabolic process • response to organic cyclic compound • lipid metabolic process • response to testosterone • response to steroid hormone • cell-cell signaling • response to peptide hormone • sex differentiation • response to organic substance • steroid catabolic process • response to nutrient levels • dibenzo-p-dioxin metabolic process • hypothalamus development • bone development • hippocampus development • oxidation-reduction process • response to follicle-stimulating hormone • response to drug • androgen metabolic process • steroid metabolic process • androgen biosynthetic process • male genitalia development • female genitalia development • progesterone metabolic process • testosterone biosynthetic process • steroid biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6716	94224
Ensembl	ENSG00000277893	ENSMUSG00000038541
UniProt	P31213	Q99N99
RefSeq (mRNA)	NM_000348	NM_053188
RefSeq (protein)	NP_000339	NP_444418
Location (UCSC)	Chr 2: 31.52 – 31.58 Mb	Chr 2: 74.02 – 74.05 Mb
PubMed search

6716

94224

ENSG00000277893

ENSMUSG00000038541

P31213

Q99N99

NM_000348

NM_053188

NP_000339

NP_444418

3-oxo-5α-steroid 4-dehydrogenase 2 is an enzyme that in humans is encoded by the SRD5A2 gene.

Steroid 5α-reductase catalyzes the conversion of the male sex hormone testosterone into the more potent androgen, dihydrotestosterone.

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).

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