The 2012–13 season was Futbol Club Barcelona's 113th in existence and the club's 82nd consecutive season in the top flight of Spanish football. The season marks the managerial debut of Tito Vilanova, who served as Pep Guardiola's longtime assistant. Vilanova assumed management of the club after Guardiola, who had managed Barcelona for the prior four seasons, declined to renew his contract.

On 29 May, Barcelona announced their first pre-season match to be against Hamburger SV in occasion of the German outfit's 125th anniversary celebration. It will be Tito Vilanova's first match in charge of the first team. The second match will be on 28 July in Tangier, Morocco, versus an all-star starting XI from the Moroccan Football League at the Stade de Tanger. This will be their first appearance in Morocco in 38 years.

On 1 June, Barcelona announced Brazilian defender Henrique will not return to team after both agreed to terminate the player's contract on 30 June. Henrique did not make an appearance with the first team and was on-loan in 2008–09 with German club Bayer Leverkusen, 2009–10, and 2010–11 with Racing de Santander and in 2011–12, with Brazilian club Palmeiras.

On 28 June, Barcelona and Valencia CF reached an agreement on the transfer of left back Jordi Alba for €14 million. The player joined the team after UEFA Euro 2012 and signed a five-year deal.

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