The 2010–11 season was Futbol Club Barcelona's 111th in existence and the club's 80th consecutive season in the top flight of Spanish football. Barcelona will start the season with a new president after Joan Laporta reached his term limit on 30 June, leaving behind a very successful club tenure.

Sandro Rosell was elected president on 13 June by securing a record total of 35,021 votes (61.35%), more than the 27,138 achieved by Laporta in 2003. Rosell began his tenure on 1 July as the 39th president in Barcelona's history.

Sir Alex Ferguson has described this squad as the best he had ever faced.

Barcelona started their transfer window only three days after the end of the 2009–10 season, by reaching an agreement with Valencia for Spanish international David Villa worth €40 million.

On 30 June, Xavier Sala-i-Martin, treasurer and director in charge of the economic area, announced that Barcelona earned a record €445.5 million in revenue during the 2009–10 season. According to Xavier, "that's the highest revenues achieved by any club, in any sport including the U.S." This means FC Barcelona is the richest club in the world in terms of revenue.

Coach Pep Guardiola later expressed disapproval of the transfer of Ukrainian centre-back Dmytro Chygrynskiy, indicating he was pressed to let him go. Speaking at a press-conference, Guardiola said, "My opinion counts, but the needs of the club go above that and that's why he was sold, I would like to have kept him." Speaking on the departing Yaya Touré, Guardiola said he would have preferred him to stay, but the player was set on moving.

On 14 July, Thierry Henry and Barcelona agreed to rescind his contract in order for Henry to become a free agent, where he subsequently signed a new four-and-a-half year contract with Major League Soccer's New York Red Bulls. He stated, "This is a new and exciting chapter in my career." The club also agreed with Pep Guardiola on a one-year extension to stay as coach of the first team, along with long-time assistant Tito Vilanova.

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