2010 Mutua Madrileña Madrid Open – Women's Doubles
| Women's Doubles | |
|---|---|
| 2010 Mutua Madrileña Madrid Open | |
| Champion |
 Serena Williams Venus Williams
|
| Runner-up |
 Gisela Dulko Flavia Pennetta
|
| Final score | 6–2, 7–5 |
Cara Black and Liezel Huber were the defending champions, but they chose not to compete together.
Black partnered up with Elena Vesnina, but they lost to Chan Yung-jan and Zheng Jie in the first round.
Huber teamed with Anabel Medina Garrigues, but they lost to Chuang Chia-jung and Vania King in the second round.
Venus and Serena Williams won in the final 6–2, 7–5 against Gisela Dulko and Flavia Pennetta.
The top four seeds received a bye into the second round.
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