2010 Mutua Madrileña Madrid Open – Women's Singles
| Women's Singles | |
|---|---|
| 2010 Mutua Madrileña Madrid Open | |
| Champion |
 Aravane Rezaï
|
| Runner-up |
 Venus Williams
|
| Final score | 6–2, 7–5 |
Dinara Safina was the defending champion, but she lost against Klára Zakopalová in the first round.
Aravane Rezaï won in the final 6–2, 7–5 against Venus Williams.
The four Rome semifinalists received a bye into the second round. They are as follows:
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