The 2010 Copa Libertadores de América Finals was the final two-legged series that determined the 2010 Copa Libertadores de América champion. It was contested between Mexican club Guadalajara and Brazilian club Internacional. The first leg was played on 11 August in Guadalajara's home field, while the second leg was played in Internacional's.

Guadalajara was playing in their first finals and is the second Mexican team to reach this stage of the Copa Libertadores. Internacional was making their third finals appearance, having finished 2nd in 1980 and winning it in 2006. To go along with the international press that normally accompanies the finals of this competition, football legend Pelé, two-times winner of the Copa Libertadores in 1962 and 1963 with Santos (as well as being three-times winner of the FIFA World Cup), handed the trophy to the winner.

The Colorados won their second title of the tournament, beating Guadalajara 6–0 on points. The refereeing team came from Colombia and Argentina, being represented by Héctor Baldassi and Óscar Ruiz,respectively. Internacional, as the champions, played the winners of the 2010 Copa Sudamericana in the 2011 Recopa Sudamericana. Internacional, by virtue of being the last South American team in the competition, was predetermined to enter the semifinals of the 2010 FIFA Club World Cup before winning the finals.

The final is played over two legs; home and away. The higher seeded team plays the second leg at home. The team that accumulates the most points —three for a win, one for a draw, zero for a loss— after the two legs is crowned the champion. The away-goals rule is not used. Should the two teams be tied on points after the second leg, the team with the best goal difference wins. If the two teams have equal goal difference, extra time is used. The extra time consists of two 15-minute halves. If the tie is still not broken, a penalty shoot-out ensues according to the Laws of the Game.

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