Rafael Nadal won his third consecutive title and Monte Carlo in 2007. The Spaniard, second seed, defeated the current world number one, Roger Federer in one hour and thirty-six minutes 6–4, 6–4.

Before the tournament began, British number one Andy Murray pulled out due to back problems. During the first round matches, there were only a few shocks, with seeded players Jarkko Nieminen and Marcos Baghdatis failing to make it past there unseeded opponents. The second round the higher seeded players due to them all receiving a bye through the first round. Roger Federer defeated Italian Andreas Seppi, and Rafael Nadal beat Juan Ignacio Chela in straight sets. The highest seeded player not to make it into the third round was third seed Nikolay Davydenko. He was defeated by Swedish player Robin Söderling. Other casualties in the second round were Fernando González, Mikhail Youzhny and David Nalbandian.

In the third round, there were no shock results, with Rafael Nadal and Roger Federer both easing into the next round in straight sets. The quarter final draw was:

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