2006 US Open – Women's Singles
| Women's Singles | |
|---|---|
| 2006 US Open | |
| Champion |
 Maria Sharapova
|
| Runner-up |
 Justine Henin-Hardenne
|
| Final score | 6–4, 6–4 |
Kim Clijsters was the defending champion, but chose not to participate that year due to injury.
Maria Sharapova won her second Grand Slam title, defeating Justine Henin-Hardenne in the final.
By reaching the final, Henin-Hardenne became the eighth woman, after Maureen Connolly, Margaret Court, Chris Evert, Martina Navratilova, Steffi Graf, Monica Seles and Martina Hingis, to reach all four Grand Slam finals in a calendar year. By losing the final, Henin-Hardenne missed an opportunity to return to World No.1 in the rankings, following Amélie Mauresmo's semi-final loss.
The seeded players are listed below.
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