The II edition of the Caribbean Series (Serie del Caribe) was held from February 21 through February 27 of 1950. It featured the champion baseball teams of Cuba, Alacranes del Almendares; Panama, Carta Vieja Yankees; Puerto Rico, Criollos de Caguas, and Venezuela, Navegantes del Magallanes. The format consisted of 12 games, each team facing the other teams twice, and the games were played at Sixto Escobar Stadium in San Juan, Puerto Rico.
The Series had to go more than the scheduled 12 games when both Panama and Puerto Rico teams ended with a similar 4-2 record. Panama clinched the title after beating Puerto Rico in a tiebreaker game. The Panamanian team, who entered the series as underdog, was led by manager/outfielder Wayne Blackburn, pitcher Chet Brewer (2-0), and third baseman Joe Tuminelli, who hit two home runs with seven runs batted in as he received Series MVP honors. The champion team also counted with pitchers John Fitzgerald, Tony Jacobs, Jean-Pierre Roy and Pat Scantlebury; catchers Roy Easterwood and Stan Andrews; second baseman Spook Jacobs, and outfielder Ted Cieslak.