17α-hydroxylase

CYP17A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RUK, 3SWZ, 4NKV, 4NKW, 4NKX, 4NKY, 4NKZ
Identifiers
Aliases	CYP17A1, CPT7, CYP17, P450C17, S17AH, cytochrome P450 family 17 subfamily A member 1
External IDs	OMIM: 609300 MGI: 88586 HomoloGene: 73875 GeneCards: CYP17A1
Targeted by Drug
abiraterone
Gene ontology Molecular function • iron ion binding • oxygen binding • metal ion binding • steroid 17-alpha-monooxygenase activity • monooxygenase activity • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • lyase activity • oxidoreductase activity • 17-alpha-hydroxyprogesterone aldolase activity Cellular component • endoplasmic reticulum membrane • membrane • axon • neuronal cell body • mitochondrion • endoplasmic reticulum Biological process • progesterone metabolic process • androgen biosynthetic process • glucocorticoid biosynthetic process • sterol metabolic process • oxidation-reduction process • hormone biosynthetic process • steroid biosynthetic process • steroid metabolic process • sex differentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1586	13074
Ensembl	ENSG00000148795	ENSMUSG00000003555
UniProt	P05093	P27786
RefSeq (mRNA)	NM_000102	NM_007809
RefSeq (protein)	NP_000093	NP_031835.3 NP_031835
Location (UCSC)	Chr 10: 102.83 – 102.84 Mb	Chr 19: 46.67 – 46.67 Mb
PubMed search

3RUK, 3SWZ, 4NKV, 4NKW, 4NKX, 4NKY, 4NKZ

1586

13074

ENSG00000148795

ENSMUSG00000003555

P05093

P27786

NM_000102

NM_007809

NP_000093

NP_031835.3
NP_031835

Cytochrome P450 17A1, also called steroid 17α-monooxygenase, 17α-hydroxylase, 17,20 lyase, or 17,20 desmolase, is an enzyme of the hydroxylase type that in humans is encoded by the CYP17A1 gene on chromosome 10. It is ubiquitously expressed in many tissues and cell types, including the zona reticularis of the adrenal cortex and zona fasciculata as well as gonadal tissues. This gene encodes a member of the superfamily of enzymes. The cytochrome P450 proteins are generally regarded as monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids, including the remarkable carbon-carbon bond scission catalyzed by this enzyme. This protein localizes to the endoplasmic reticulum. It has both 17α-hydroxylase and 17,20-lyase activities, and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. More specifically, CYP17A1 acts upon pregnenolone and progesterone to add a hydroxyl (-OH) group at carbon 17 of the steroid D ring (the hydroxylase activity), or acts upon 17α-hydroxyprogesterone and 17α-hydroxypregnenolone to split the side-chain off the steroid nucleus (the lyase activity). The CYP17A1 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

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Wikipedia