Α1A-adrenergic

ADRA1A
Identifiers
Aliases	ADRA1A, ADRA1C, ADRA1L1, ALPHA1AAR, adrenoceptor alpha 1A
External IDs	MGI: 104773 HomoloGene: 68078 GeneCards: ADRA1A
Targeted by Drug
epinephrine, methoxamine, norepinephrine, oxymetazoline, phenylephrine, diazepam, alfuzosin, bmy-7378 free base, cabergoline, clozapine, cyproheptadine, doxazosin, indoramin, ketanserin, lisuride, mianserin, NAN 190, phentolamine, piribedil, risperidone, ritanserin, roxindole, silodosin, spiperone, spiroxatrine, tamsulosin, terazosin, terguride, WB-4101, prazosin
Gene ontology Molecular function • signal transducer activity • adrenergic receptor activity • protein heterodimerization activity • G-protein coupled receptor activity • alpha1-adrenergic receptor activity Cellular component • T-tubule • nuclear membrane • integral component of membrane • nucleus • integral component of plasma membrane • membrane • Z disc • plasma membrane Biological process • positive regulation of cardiac muscle contraction • negative regulation of cell proliferation • response to hormone • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure • positive regulation of MAPK cascade • intracellular signal transduction • positive regulation of ERK1 and ERK2 cascade • signal transduction • organ growth • cell-cell signaling • positive regulation of smooth muscle contraction • activation of phospholipase C activity • pilomotor reflex • regulation of vasoconstriction • positive regulation of heart rate • positive regulation of synaptic transmission, GABAergic • positive regulation of systemic arterial blood pressure • G-protein coupled receptor signaling pathway • micturition • calcium ion transport into cytosol • positive regulation of action potential • positive regulation of the force of heart contraction by epinephrine-norepinephrine • apoptotic process • smooth muscle contraction • phospholipase C-activating G-protein coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • aging • regulation of cardiac muscle contraction • positive regulation of heart rate by epinephrine-norepinephrine • positive regulation of protein kinase C signaling • negative regulation of Rho protein signal transduction • regulation of muscle contraction • response to drug • cell growth • adult heart development • negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure • positive regulation of cytosolic calcium ion concentration • positive regulation of vasoconstriction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	148	11549
Ensembl	ENSG00000120907	ENSMUSG00000045875
UniProt	P35348	P97718
RefSeq (mRNA)	NM_000680 NM_033302 NM_033303 NM_033304 NM_001322502 NM_001322503 NM_001322504	NM_001271759 NM_001271760 NM_001271761 NM_013461
RefSeq (protein)	NP_000671 NP_001309431 NP_001309432 NP_001309433 NP_150645 NP_150646 NP_150647	NP_001258689.1 NP_038489.2 NP_001258688 NP_001258689 NP_001258690 NP_038489
Location (UCSC)	Chr 8: 26.75 – 26.87 Mb	Chr 14: 66.64 – 66.73 Mb
PubMed search

148

11549

ENSG00000120907

ENSMUSG00000045875

P35348

P97718

NM_001322503
NM_001322504

NM_001271759
NM_001271760
NM_001271761
NM_013461

NP_150646
NP_150647

NP_038489

The alpha-1A adrenergic receptor (α_1A adrenoreceptor), also known as ADRA1A, formerly known also as the alpha-1C adrenergic receptor, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it. There is no longer a subtype α_1C receptor. At one time, there was a subtype known as α_1C, but it was found to be identical to the previously discovered α_1A receptor subtype. To avoid confusion, the naming convention was continued with the letter D.

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Wikipedia