ZFP36L1

ZFP36L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W0V, 1W0W
Identifiers
Aliases	ZFP36L1, BRF1, Berg36, ERF-1, ERF1, RNF162B, TIS11B, cMG1, ZFP36 ring finger protein-like 1, ZFP36 ring finger protein like 1
External IDs	MGI: 107946 HomoloGene: 31276 GeneCards: ZFP36L1
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • AU-rich element binding • metal ion binding • protein binding • mRNA binding • 14-3-3 protein binding • RNA binding • mRNA 3'-UTR AU-rich region binding Cellular component • cytoplasm • nucleus • cytosol • P-body • intracellular ribonucleoprotein complex Biological process • spongiotrophoblast layer development • mRNA catabolic process • multicellular organism growth • embryonic organ development • chorio-allantoic fusion • vasculogenesis • proepicardium development • heart development • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • neural tube development • cell proliferation • regulation of translation • apoptotic process • T cell differentiation in thymus • regulation of gene expression • negative regulation of erythrocyte differentiation • cellular response to insulin stimulus • cellular response to phorbol 13-acetate 12-myristate • ERK1 and ERK2 cascade • positive regulation of intracellular mRNA localization • cellular response to glucocorticoid stimulus • cellular response to transforming growth factor beta stimulus • regulation of keratinocyte differentiation • response to wounding • positive regulation of monocyte differentiation • regulation of transcription, DNA-templated • cellular response to hypoxia • regulation of keratinocyte apoptotic process • regulation of keratinocyte proliferation • phosphatidylinositol 3-kinase signaling • cellular response to tumor necrosis factor • cellular response to epidermal growth factor stimulus • regulation of mRNA 3'-end processing • MAPK cascade • mRNA processing • multicellular organism development • nuclear-transcribed mRNA catabolic process, deadenylation-independent decay • p38MAPK cascade • regulation of mRNA stability • protein kinase B signaling • cellular response to fibroblast growth factor stimulus • regulation of B cell differentiation • positive regulation of fat cell differentiation • regulation of myoblast differentiation • mesendoderm development • mRNA transport • 3'-UTR-mediated mRNA destabilization • cellular response to cAMP • cellular response to peptide hormone stimulus • cellular response to salt stress • regulation of stem cell proliferation • cellular response to raffinose • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • negative regulation of mitotic cell cycle phase transition • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	677	12192
Ensembl	ENSG00000185650	ENSMUSG00000021127
UniProt	Q07352	P23950
RefSeq (mRNA)	NM_004926 NM_001244698 NM_001244701	NM_007564
RefSeq (protein)	NP_001231627 NP_001231630 NP_004917	NP_031590
Location (UCSC)	Chr 14: 68.79 – 68.8 Mb	Chr 12: 80.11 – 80.11 Mb
PubMed search

1W0V, 1W0W

677

12192

ENSG00000185650

ENSMUSG00000021127

Q07352

P23950

NM_004926
NM_001244698
NM_001244701

NM_007564

NP_001231627
NP_001231630
NP_004917

NP_031590

Butyrate response factor 1 is a protein that in humans is encoded by the ZFP36L1 gene.

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This RNA binding protein most likely functions in regulating the response to growth factors.

...
Wikipedia