ZFP36

ZFP36
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4J8S
Identifiers
Aliases	ZFP36, G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36, ZFP36 ring finger protein
External IDs	MGI: 99180 HomoloGene: 2558 GeneCards: ZFP36
Gene ontology Molecular function • DNA binding • C-C chemokine binding • 14-3-3 protein binding • AU-rich element binding • metal ion binding • protein binding • single-stranded RNA binding • mRNA 3'-UTR AU-rich region binding • enzyme binding • mRNA binding • protein kinase binding • RNA binding • heat shock protein binding • RNA polymerase binding Cellular component • cytoplasm • cytoplasmic stress granule • nucleus • RISC-loading complex • ribonucleoprotein complex • Dcp1-Dcp2 complex • exosome (RNase complex) • P-body • cytosol • CCR4-NOT complex • intracellular ribonucleoprotein complex Biological process • nuclear-transcribed mRNA poly(A) tail shortening • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening • mRNA catabolic process • regulation of tumor necrosis factor production • negative regulation of transcription from RNA polymerase II promoter • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • miRNA mediated inhibition of translation • response to starvation • 3'-UTR-mediated mRNA stabilization • negative regulation of erythrocyte differentiation • cellular response to lipopolysaccharide • cellular response to tumor necrosis factor • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA • regulation of keratinocyte apoptotic process • regulation of keratinocyte proliferation • positive regulation of fat cell differentiation • cellular response to fibroblast growth factor stimulus • cellular response to granulocyte macrophage colony-stimulating factor stimulus • negative regulation of viral transcription • regulation of keratinocyte differentiation • negative regulation of interleukin-2 biosynthetic process • response to wounding • positive regulation of gene silencing by miRNA • regulation of mRNA stability • MAPK cascade • cellular response to glucocorticoid stimulus • cellular response to epidermal growth factor stimulus • positive regulation of intracellular mRNA localization • p38MAPK cascade • nuclear-transcribed mRNA catabolic process, deadenylation-independent decay • gene silencing by RNA • mRNA transport • 3'-UTR-mediated mRNA destabilization • negative regulation of polynucleotide adenylyltransferase activity • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7538	22695
Ensembl	ENSG00000128016	ENSMUSG00000044786
UniProt	P26651	P22893
RefSeq (mRNA)	NM_003407	NM_011756
RefSeq (protein)	NP_003398	NP_035886
Location (UCSC)	Chr 19: 39.41 – 39.41 Mb	Chr 7: 28.38 – 28.38 Mb
PubMed search

4J8S

7538

22695

ENSG00000128016

ENSMUSG00000044786

P26651

P22893

NM_003407

NM_011756

NP_003398

NP_035886

Tristetraprolin (TTP), also known as zinc finger protein 36 homolog (ZFP36), is a protein that in humans, mice and rats is encoded by the ZFP36 gene. It is a member of the TIS11 (TPA-induced sequence) family, along with butyrate response factors 1 and 2.

TTP binds to AU-rich elements (AREs) in the 3'-untranslated regions (UTRs) of the mRNAs of some cytokines and promotes their degradation. For example, TTP is a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its mRNA. Mice deficient in TTP develop a complex syndrome of inflammatory diseases.

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