William Berkeley Lewis (1784 – November 12, 1866) was born in Loudoun County, Virginia, and later moved near Nashville, Tennessee, in 1809. Major Lewis served as quartermaster under General Andrew Jackson. Later, in politics, he was a manager of Jackson and retained considerable influence until Jackson's second term as President of the United States. Jackson appointed Lewis as second auditor of the Treasury, a position he was able to retain until the Polk administration.
Lewis married Margaret Lewis, daughter of William T. Lewis of Tennessee (John Eaton first married Margaret's sister Myra), though she died after a year of marriage. He later married Adelaide Stokes Chambers, daughter of Montfort Stokes of North Carolina.