Willem Hendrik de Vriese (August 11, 1806 – January 23, 1862) was a Dutch botanist and physician born in Oosterhout, North Brabant.
He studied medicine at the University of Leiden, earning his doctorate in 1831. Afterwards he practiced medicine in Rotterdam, where he also gave classes in botany at the medical school. In 1834, he was appointed associate professor of botany at the Athenaeum Illustré in Amsterdam, and in 1841 was promoted to full professor. In 1845, he became a professor of botany at Leiden and successor to Caspar Georg Carl Reinwardt (1773–1854) at the Hortus Botanicus Leiden. He became a member of the Royal Dutch Academy of Sciences in 1838.
In October 1857, he was commissioned to conduct botanical investigations in the Dutch East Indies, and consequently spent the following years performing research in Java, Borneo, Sumatra and the Moluccas. In March 1861, he returned to the Netherlands in a weakened state, and died in Leiden several months later.
Among his written works was the first part of "Hortus Spaarne-Bergensis" (1839), a catalogue of banker Adriaan van der Hoop's exotic plant collection. He was an editor of Caspar Reinwardt's scientific works, two years after Reinwardt's death, he published "Plantae Indiae Batavae Orientalis: quas, in itinere per insulas Archipelagi Indici Javam, Amboinam, Celebem, Ternatam, aliasque, annis 1815-1821 exploravit Casp. Georg. Carol. Reinwardt" (1856). He was the author of a memoir on Franz Julius Ferdinand Meyen as well as of noteworthy treatises on cinchona (1855), vanilla (1856) and camphor (1856). Also, he published monographs on the genus Rafflesia and of the botanical family Marattiaceae (with biologist Pieter Harting 1812-1885).