Werner syndrome ATP-dependent helicase

WRN

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2AXL, 2DGZ, 2E1E, 2E1F, 2FBT, 2FBV, 2FBX, 2FBY, 2FC0, 3AAF

Identifiers

Aliases

WRN, RECQ3, RECQL2, RECQL3, Werner syndrome RecQ like helicase

External IDs

OMIM: 604611 MGI: 109635 HomoloGene: 6659 GeneCards: WRN

EC number

3.1.-.-

Gene location (Human)

Chr.	Chromosome 8 (human)

Band	8p12	Start	31,033,801 bp
Band	8p12	End	31,173,769 bp

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)

Band	8 A3\|8 20.3 cM	Start	33,234,384 bp
Band	8 A3\|8 20.3 cM	End	33,385,527 bp

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• DNA binding • nucleotide binding • manganese ion binding • protein homodimerization activity • helicase activity • protein complex binding • ATP-dependent DNA helicase activity • bubble DNA binding • chromatin binding • ATP-dependent helicase activity • metal ion binding • G-quadruplex DNA binding • DNA helicase activity • ATPase activity • protein binding • catalytic activity • 3'-5' exonuclease activity • Y-form DNA binding • nucleic acid binding • nuclease activity • 3'-5' DNA helicase activity • four-way junction helicase activity • ATP binding • magnesium ion binding • hydrolase activity • ATP-dependent 3'-5' DNA helicase activity • exonuclease activity • telomeric D-loop binding • 3'-flap-structured DNA binding • four-way junction DNA binding • forked DNA-dependent helicase activity • telomeric G-quadruplex DNA binding • 8-hydroxy-2'-deoxyguanosine DNA binding
Cellular component	• centrosome • intracellular • nucleoplasm • nucleolus • neuron projection • MutLalpha complex • nucleus • cytoplasm • nuclear speck • chromosome, telomeric region • replication fork
Biological process	• regulation of apoptotic process • positive regulation of hydrolase activity • DNA recombination • nucleolus to nucleoplasm transport • cellular response to starvation • DNA metabolic process • aging • response to oxidative stress • replicative cell aging • cellular response to DNA damage stimulus • cell aging • regulation of growth rate • brain development • cellular metabolic process • cellular response to gamma radiation • replication fork processing • multicellular organism aging • metabolism • nucleobase-containing compound metabolic process • response to UV-C • base-excision repair • strand displacement • DNA synthesis involved in DNA repair • double-strand break repair • DNA repair • nucleic acid phosphodiester bond hydrolysis • regulation of signal transduction by p53 class mediator • double-strand break repair via homologous recombination • DNA duplex unwinding • DNA replication • telomeric D-loop disassembly • t-circle formation • positive regulation of strand invasion • telomere maintenance • G-quadruplex DNA unwinding
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7486


22427

Ensembl


ENSG00000165392


ENSMUSG00000031583

UniProt


Q14191


O09053

RefSeq (mRNA)


NM_000553


NM_001122822 NM_011721

RefSeq (protein)


NP_000544


NP_001116294 NP_035851

Location (UCSC)

Chr 8: 31.03 – 31.17 Mb

Chr 8: 33.23 – 33.39 Mb

PubMed search

2AXL, 2DGZ, 2E1E, 2E1F, 2FBT, 2FBV, 2FBX, 2FBY, 2FC0, 3AAF

NM_001122822
NM_011721

NP_000544

NP_001116294
NP_035851

...
Wikipedia