WNT4

WNT4
Identifiers
Aliases	WNT4, SERKAL, WNT-4, Wnt family member 4
External IDs	OMIM: 603490 MGI: 98957 HomoloGene: 22529 GeneCards: WNT4
Gene ontology Molecular function • transcription corepressor activity • receptor binding • frizzled binding • receptor agonist activity Cellular component • cytoplasm • endocytic vesicle membrane • endoplasmic reticulum lumen • extracellular region • cell surface • extracellular exosome • proteinaceous extracellular matrix • plasma membrane • Golgi lumen • extracellular space Biological process • non-canonical Wnt signaling pathway • T cell differentiation in thymus • positive regulation of canonical Wnt signaling pathway • negative regulation of male gonad development • mesonephros development • androgen biosynthetic process • gamete generation • negative regulation of wound healing • metanephros development • cellular response to transforming growth factor beta stimulus • positive regulation of collagen biosynthetic process • mesonephric tubule development • cell fate commitment • mammary gland epithelium development • kidney development • negative regulation of cell differentiation • metanephric nephron morphogenesis • negative regulation of apoptotic signaling pathway • female sex determination • tube morphogenesis • smooth muscle cell differentiation • negative regulation of gene expression • female gonad development • positive regulation of transcription, DNA-templated • positive regulation of GTPase activity • branching involved in ureteric bud morphogenesis • kidney morphogenesis • nephron development • paramesonephric duct development • thyroid-stimulating hormone-secreting cell differentiation • hormone metabolic process • negative regulation of steroid biosynthetic process • tertiary branching involved in mammary gland duct morphogenesis • cell differentiation • male gonad development • positive regulation of aldosterone biosynthetic process • positive regulation of bone mineralization • anatomical structure development • somatotropin secreting cell differentiation • negative regulation of testicular blood vessel morphogenesis • metanephric mesenchymal cell differentiation • sex differentiation • metanephric nephron development • oocyte development • negative regulation of cell migration • positive regulation of osteoblast differentiation • renal vesicle formation • neuron differentiation • regulation of cell-cell adhesion • epithelial to mesenchymal transition • canonical Wnt signaling pathway • negative regulation of transcription, DNA-templated • branching morphogenesis of an epithelial tube • metanephric tubule formation • non-canonical Wnt signaling pathway via MAPK cascade • negative regulation of testosterone biosynthetic process • embryonic epithelial tube formation • positive regulation of cortisol biosynthetic process • positive regulation of dermatome development • cellular response to starvation • adrenal gland development • multicellular organism development • negative regulation of fibroblast growth factor receptor signaling pathway • renal vesicle induction • positive regulation of meiotic nuclear division • positive regulation of focal adhesion assembly • liver development • immature T cell proliferation in thymus • positive regulation of stress fiber assembly • establishment of protein localization to plasma membrane • mesenchymal to epithelial transition • Wnt signaling pathway • negative regulation of canonical Wnt signaling pathway • positive regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54361	22417
Ensembl	ENSG00000162552	ENSMUSG00000036856
UniProt	P56705	P22724
RefSeq (mRNA)	NM_030761	NM_009523
RefSeq (protein)	NP_110388	NP_033549.1 NP_033549
Location (UCSC)	Chr 1: 22.12 – 22.14 Mb	Chr 4: 137.28 – 137.3 Mb
PubMed search

54361

22417

ENSG00000162552

ENSMUSG00000036856

P56705

P22724

NM_030761

NM_009523

NP_110388

NP_033549.1
NP_033549

WNT4 is a secreted protein that in humans is encoded by the Wnt4 gene, found on chromosome 1. It promotes female sex development and represses male sex development. Loss of function can have serious consequences, such as female to male sex reversal.

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and embryogenesis.

WNT4 is involved in a couple features of pregnancy as a downstream target of BMP2. For example, it regulates endometrial stromal cell proliferation, survival, and differentiation. These processes are all necessary for the development of an embryo. Ablation in female mice results in subfertility, with defects in implantation and decidualization. For instance, there is a decrease in responsiveness to progesterone signaling. Furthermore, postnatal uterine differentiation is characterized by a reduction in gland numbers and the stratification of the luminal epithelium.

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