Bone morphogenetic protein 2

BMP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ES7, 1REU, 1REW, 2GOO, 2H62, 2H64, 2QJ9, 2QJA, 2QJB, 3BK3, 3BMP, 4MID, 4N1D, 4UHY, 4UHZ, 4UI0, 4UI1, 4UI2
Identifiers
Aliases	BMP2, BDA2, BMP2A, bone morphogenetic protein 2
External IDs	OMIM: 112261 MGI: 88177 HomoloGene: 926 GeneCards: BMP2
Gene location (Human) Chr. Chromosome 20 (human) Band 20p12.3 Start 6,767,664 bp End 6,780,280 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 F2|2 65.21 cM Start 133,552,159 bp End 133,562,885 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor binding • cytokine activity • co-receptor binding • phosphatase activator activity • growth factor activity • BMP receptor binding • protein binding • retinol dehydrogenase activity • SMAD binding • protein heterodimerization activity • transforming growth factor beta receptor binding Cellular component • extracellular region • cell surface • BMP receptor complex • extracellular space • intracellular membrane-bounded organelle Biological process • skeletal system development • positive regulation of Wnt signaling pathway by BMP signaling pathway • positive regulation of protein phosphorylation • embryo development • mesenchyme development • negative regulation of cell cycle • odontogenesis of dentin-containing tooth • telencephalon regionalization • protein phosphorylation • atrioventricular valve morphogenesis • proteoglycan metabolic process • mesenchymal cell differentiation • pericardium development • positive regulation of ERK1 and ERK2 cascade • BMP signaling pathway involved in heart induction • animal organ morphogenesis • inner ear development • cardiocyte differentiation • negative regulation of canonical Wnt signaling pathway • negative regulation of cell proliferation • positive regulation of p38MAPK cascade • pathway-restricted SMAD protein phosphorylation • cell fate commitment • regulation of transcription, DNA-templated • SMAD protein signal transduction • ossification • in utero embryonic development • mesenchymal cell proliferation involved in ureteric bud development • regulation of odontogenesis of dentin-containing tooth • negative regulation of gene expression • positive regulation of transcription, DNA-templated • positive regulation of Wnt signaling pathway • heart development • telencephalon development • branching involved in ureteric bud morphogenesis • negative regulation of Wnt signaling pathway involved in heart development • cartilage development • bone mineralization involved in bone maturation • positive regulation of cartilage development • positive regulation of neuron differentiation • positive regulation of cell differentiation • thyroid-stimulating hormone-secreting cell differentiation • inflammatory response • positive regulation of fat cell differentiation • negative regulation of steroid biosynthetic process • positive regulation of MAPK cascade • Notch signaling pathway • bone mineralization • cell differentiation • chondrocyte differentiation • corticotropin hormone secreting cell differentiation • positive regulation of astrocyte differentiation • positive regulation of bone mineralization • cellular response to organic cyclic compound • positive regulation of ossification • negative regulation of transcription from RNA polymerase II promoter • positive regulation of epithelial to mesenchymal transition • positive regulation of phosphatase activity • negative regulation of calcium-independent cell-cell adhesion • positive regulation of osteoblast differentiation • activation of MAPK activity • protein destabilization • embryonic heart tube anterior/posterior pattern specification • osteoblast differentiation • epithelial to mesenchymal transition • positive regulation of protein binding • negative regulation of transcription, DNA-templated • positive regulation of odontogenesis • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus • negative regulation of aldosterone biosynthetic process • positive regulation of osteoblast proliferation • response to hypoxia • positive regulation of endothelial cell proliferation • positive regulation of cell migration • negative regulation of cortisol biosynthetic process • cell-cell signaling • positive regulation of pathway-restricted SMAD protein phosphorylation • cellular response to growth factor stimulus • cellular response to BMP stimulus • cardiac muscle tissue morphogenesis • endocardial cushion morphogenesis • multicellular organism development • negative regulation of cardiac muscle cell differentiation • positive regulation of apoptotic process • negative regulation of insulin-like growth factor receptor signaling pathway • oxidation-reduction process • positive regulation of transcription from RNA polymerase II promoter • cardiac epithelial to mesenchymal transition • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • positive regulation of gene expression • BMP signaling pathway • cardiac muscle cell differentiation • cell development • regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	650	12156
Ensembl	ENSG00000125845	ENSMUSG00000027358
UniProt	P12643	P21274
RefSeq (mRNA)	NM_001200	NM_007553
RefSeq (protein)	NP_001191	NP_031579
Location (UCSC)	Chr 20: 6.77 – 6.78 Mb	Chr 20: 133.55 – 133.56 Mb
PubMed search

1ES7, 1REU, 1REW, 2GOO, 2H62, 2H64, 2QJ9, 2QJA, 2QJB, 3BK3, 3BMP, 4MID, 4N1D, 4UHY, 4UHZ, 4UI0, 4UI1, 4UI2

650

12156

ENSG00000125845

ENSMUSG00000027358

P12643

P21274

...
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