Vernon Ingram
| Vernon Martin Ingram | |
|---|---|
| Born |
19 May 1924 Breslau, Germany |
| Died | 17 August 2006 (aged 82) Boston, Massachusetts |
| Residence | Germany, United Kingdom, United States |
| Nationality | German |
| Fields | Biologist |
| Institutions | MIT |
| Alma mater | University of London |
| Doctoral advisor | Fred Barrow |
| Notable awards | William Allan Award (1967) |
| Spouse | Elizabeth Ingram |
| Children | Peter, Jennifer |
Vernon Martin Ingram, Ph.D., FRS (19 May 1924 – 17 August 2006) was a German American professor of biology at the Massachusetts Institute of Technology.
Ingram was born in Breslau, Lower Silesia. When he was 14, he and his family left Nazi Germany because of their opposition to Nazism and settled in England.
During the Second World War, Ingram worked at a chemical factory producing drugs for the war effort and at night studied at Birkbeck College at the University of London. He received a bachelor's degree in chemistry in 1945 and a PhD in organic chemistry in 1949.
After receiving his doctorate, Ingram worked at postdoctoral appointments at the Rockefeller Institute and Yale University. At Rockefeller, he worked with Moses Kunitz on crystallizing proteins. While at Yale, he studied peptide chemistry with Joseph Fruton. In 1952, Ingram returned to England and started working at the Cavendish Laboratory at the University of Cambridge, studying protein chemistry.
In 1956, Ingram, John A. Hunt, and Antony O. W. Stretton determined that the change in the hemoglobin molecule in sickle cell disease and trait was the substitution of the glutamic acid in position 6 of the β-chain of the normal protein by valine. Ingram used electrophoresis and chromatography to show that the amino acid sequence of normal human and sickle cell anemia hemoglobins differed due to a single substituted amino acid residue. Much of this work was done with the support of Max Perutz and Francis Crick. Ingram won the William Allan Award from the American Society of Human Genetics in 1967.
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