VPREB3

VPREB3
Identifiers
Aliases	VPREB3, 8HS20, N27C7-2, pre-B lymphocyte 3, V-set pre-B cell surrogate light chain 3
External IDs	MGI: 98938 HomoloGene: 7598 GeneCards: VPREB3
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.23|22q11 Start 23,752,743 bp End 23,754,468 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 C1 Start 75,943,057 bp End 75,949,657 bp
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	29802	22364
Ensembl	ENSG00000128218	ENSMUSG00000000903
UniProt	Q9UKI3	n/a
RefSeq (mRNA)	NM_013378	NM_009514
RefSeq (protein)	NP_037510	n/a
Location (UCSC)	Chr 22: 23.75 – 23.75 Mb	Chr 22: 75.94 – 75.95 Mb
PubMed search

29802

22364

ENSG00000128218

ENSMUSG00000000903

Q9UKI3

n/a

NM_013378

NM_009514

NP_037510

n/a

Pre-B lymphocyte protein 3 is a protein that in humans is encoded by the VPREB3 gene.

The VPREB3 gene product is the human homologue of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-lymphocyte differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. The VPREB3 protein apparently associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of VPREB3 is not known, but it may contribute to mu chain transport in pre-B cells. In humans, besides the bone marrow and secondary lymphoid tissues such as the tonsils, the VPREB3 protein is also present in Purkinje cells of the cerebellum and in the zona glomerulosa of the adrenal.

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Wikipedia