VPREB1

VPREB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2H32, 2H3N, 3BJ9
Identifiers
Aliases	VPREB1, IGI, IGVPB, VPREB, CD179a, pre-B lymphocyte 1, V-set pre-B cell surrogate light chain 1
External IDs	MGI: 98937 HomoloGene: 84741 GeneCards: VPREB1
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.22 Start 22,244,675 bp End 22,245,515 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 A3|16 11.14 cM Start 17,980,565 bp End 17,981,080 bp
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7441	22363
Ensembl	ENSG00000169575	ENSMUSG00000059280
UniProt	P12018	P13373
RefSeq (mRNA)	NM_007128 NM_001303509	NM_016983
RefSeq (protein)	NP_001290438 NP_009059	NP_058679
Location (UCSC)	Chr 22: 22.24 – 22.25 Mb	Chr 22: 17.98 – 17.98 Mb
PubMed search

2H32, 2H3N, 3BJ9

7441

22363

ENSG00000169575

ENSMUSG00000059280

P12018

P13373

NM_007128
NM_001303509

NM_016983

NP_001290438
NP_009059

NP_058679

Immunoglobulin iota chain is a protein that in humans is encoded by the VPREB1 gene. VPREB1 has also recently been designated CD179A (cluster of differentiation 179A).

CD179a (VpreB) is a 126 aa-long polypeptide with apparent MW of 16-18 kDa. It is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. CD179a has an Ig V domain-like structure, but lacks the last beta-strand (beta7) of a typical V domain. Instead, it has a carboxyl terminal end that shows no sequence homologies to any other proteins. CD179a associates non-covalently with CD179b (lambda5 or lambda-like) carrying an Ig C domain-like structure to form an Ig light chain-like structure, which is called the surrogate light chain or pseudo light chain. In this complex, the incomplete V domain of CD179a appears to be complemented by the extra beta7 strand of CD179b. On the surface of early preB cells, CD179a/CD179b surrogate light chain is disulfide-linked to membrane-bound Ig mu heavy chain in association with a signal transducer CD79a/CD79b heterodimer to form a B cell receptor-like structure, so-called preB cell receptor (preBCR). Though no CD179a-related human disease or pathology has been reported yet, the deficiency of other components of preB cell receptor such as CD179b, Ig mu heavy chain and CD79a has been shown to result in severe impairment of B cell development and agammaglobulinemia in human. PreBCR transduces signals for: 1) cellular proliferation, differentiation from the proB cell to preB cell stage, 2) allelic exclusion at the Ig heavy chain gene locus, and 3) promotion of Ig light chain gene rearrangements. Thus, preBCR functions as a checkpoint in early B cell development to monitor the production of Ig mu heavy chain through a functional rearrangement of Ig heavy chain gene as well as the potency of Ig mu heavy chain to associate with Ig light chain.

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Wikipedia