VMAT1

SLC18A1
Identifiers
Aliases	SLC18A1, CGAT, VAT1, VMAT1, Vesicular monoamine transporter 1, solute carrier family 18 member A1
External IDs	MGI: 106684 HomoloGene: 20664 GeneCards: SLC18A1
Targeted by Drug
ketanserin, reserpine, tetrabenazine
Gene ontology Molecular function • monoamine transmembrane transporter activity • drug transmembrane transporter activity • serotonin transmembrane transporter activity Cellular component • integral component of membrane • clathrin-sculpted monoamine transport vesicle membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum • cytoplasmic vesicle membrane • cytoplasmic vesicle • integral component of plasma membrane • presynapse Biological process • drug transmembrane transport • drug transport • monoamine transport • transport • neurotransmitter transport • aminergic neurotransmitter loading into synaptic vesicle • serotonin transport • transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6570	110877
Ensembl	ENSG00000036565	ENSMUSG00000036330
UniProt	P54219	Q8R090
RefSeq (mRNA)	NM_001135691 NM_001142324 NM_001142325 NM_003053	NM_153054
RefSeq (protein)	NP_001129163 NP_001135796 NP_001135797 NP_003044	NP_694694.1 NP_694694
Location (UCSC)	Chr 8: 20.14 – 20.18 Mb	Chr 8: 69.04 – 69.09 Mb
PubMed search

6570

110877

ENSG00000036565

ENSMUSG00000036330

P54219

Q8R090

NM_001135691
NM_001142324
NM_001142325
NM_003053

NM_153054

NP_001129163
NP_001135796
NP_001135797
NP_003044

NP_694694.1
NP_694694

Vesicular monoamine transporter 1 (VMAT1) also known as chromaffin granule amine transporter (CGAT) or solute carrier family 18 member 1 (SLC18A1) is a protein that in humans is encoded by the SLC18A1 gene. VMAT1 is an integral membrane protein, which is embedded in synaptic vesicles and serves to transfer monoamines, such as norepinephrine, epinephrine, dopamine, and serotonin, between the cytosol and synaptic vesicles. SLC18A1 is an isoform of the vesicular monoamine transporter.

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Wikipedia