VAC14

VAC14
Identifiers
Aliases	VAC14, ArPIKfyve, TAX1BP2, TRX, Vac14, PIKFYVE complex component
External IDs	MGI: 2157980 HomoloGene: 6528 GeneCards: VAC14
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.1-q22.2 Start 70,687,439 bp End 70,801,161 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 D3-E1|8 57.59 cM Start 110,618,585 bp End 110,720,398 bp
Gene ontology Molecular function • protein binding • receptor activity Cellular component • organelle membrane • Golgi membrane • endosome • early endosome membrane • endosome membrane • PAS complex • endoplasmic reticulum • late endosome membrane • membrane • intracellular membrane-bounded organelle Biological process • phosphatidylinositol biosynthetic process • viral process • signal transduction • regulation of lipid kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55697	234729
Ensembl	ENSG00000103043	ENSMUSG00000010936
UniProt	Q08AM6	Q80WQ2
RefSeq (mRNA)	NM_018052 NM_001351157	NM_146216
RefSeq (protein)	NP_060522 NP_001338086	NP_666328
Location (UCSC)	Chr 16: 70.69 – 70.8 Mb	Chr 16: 110.62 – 110.72 Mb
PubMed search

55697

234729

ENSG00000103043

ENSMUSG00000010936

Q08AM6

Q80WQ2

NM_018052
NM_001351157

NM_146216

NP_060522
NP_001338086

NP_666328

Protein VAC14 homolog, also known as ArPIKfyve (Associated Regulator of PIKfyve), is a protein that in humans is encoded by the VAC14 gene.

The content of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. The ArPIKfyve protein scaffolds a trimolecular complex to tightly regulate the level of PtdIns(3,5)P2. Other components of this complex are the PtdIns(3,5)P2-synthesizing enzyme PIKFYVE and the Sac1-domain-containing PtdIns(3,5)P2 5-phosphatase Sac3, encoded by the human gene FIG4. VAC14 functions as an activator of PIKFYVE. Studies in VAC14 knockout mice indicate that, in addition to increasing the PtdIns(3,5)P2-producing activity of PIKfyve, VAC14 also controls the steady-state levels of another rare phosphoinositide linked to PIKfyve enzyme activity – phosphatidylinositol 5-phosphate.

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