Uzzano is a comune (municipality) in the Province of Pistoia in the Italian region Tuscany, located about 45 kilometres (28 miles) west of Florence and about 15 kilometres (9 mi) southwest of Pistoia. As of 31 December 2005, it had a population of 5,019 and an area of 7.8 square kilometres (3.0 sq mi).

The municipality of Uzzano contains the frazioni (subdivisions, mainly villages and hamlets) Fornaci, Forone, Molinaccio, La Costa, Sant'Allucio, Santa Lucia, and Torricchio.

Uzzano borders the following municipalities: Buggiano, Chiesina Uzzanese, Pescia, Ponte Buggianese.

The origin of Uzzano's hilltop settlement dates to the Lombard period, though the first mention of it dates about 1000 AD, when its castello was in the possession of a noble family of Lucca, of Lombard lineage, who were signori of Uzzano and of Montichiari and Vivinaia. In 1202 the comune gained local autonomy, remaining nevertheless a dependency of Lucca. In the 14th century Uzzano, like other comuni of the Valdinievole, passed under the dominion of Florence, with which it was joined until the unification of Italy, when it was returned to the jurisdiction of Lucca, and the separated by the creation of the province of Pistoia (1928). In 1963, the southern section of Uzzano was separated to form the comune of Chiesina Uzzanese. Uzzano also means fighter in old Tuscan.

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