Urocortin

UCN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RMF, 3N96
Identifiers
Aliases	UCN, UI, UROC, urocortin
External IDs	OMIM: 600945 MGI: 1276123 HomoloGene: 2515 GeneCards: UCN
Gene location (Human) Chr. Chromosome 2 (human) Band 2p23.3 Start 27,307,400 bp End 27,308,445 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 B1|5 17.11 cM Start 31,138,063 bp End 31,138,829 bp
Gene ontology Molecular function • histone deacetylase inhibitor activity • hormone activity • corticotropin-releasing hormone receptor 1 binding • corticotropin-releasing hormone receptor 2 binding • protein binding • neuropeptide hormone activity • G-protein coupled receptor binding Cellular component • axon terminus • perikaryon • varicosity • axon • dendrite • neuronal cell body • extracellular region Biological process • positive regulation of collagen biosynthetic process • positive regulation of cAMP biosynthetic process • G-protein coupled receptor signaling pathway • negative regulation of histone deacetylation • activation of protein kinase A activity • response to estradiol • positive regulation of protein phosphorylation • associative learning • startle response • gastric emptying • negative regulation of blood pressure • female pregnancy • negative regulation of gastric acid secretion • negative regulation of apoptotic process • response to glucocorticoid • sensory perception of sound • pancreatic juice secretion • response to oxidative stress • negative regulation of appetite • positive regulation of translation • negative regulation of gene expression • positive regulation of corticotropin secretion • negative regulation of cell death • positive regulation of peptidyl-serine phosphorylation • positive regulation of DNA replication • aerobic respiration • positive regulation of calcium ion import • positive regulation of cell growth • positive regulation of vascular permeability • positive regulation of gene expression • drinking behavior • response to pain • positive regulation of cardiac muscle contraction • feeding behavior • positive regulation of interleukin-6 production • response to auditory stimulus • learning or memory • social behavior • regulation of synaptic transmission, glutamatergic • inflammatory response • neuropeptide signaling pathway • neuron projection development • negative regulation of necrotic cell death • positive regulation of behavioral fear response • negative regulation of cell size • positive regulation of transcription from RNA polymerase II promoter • negative regulation of neuron death • negative regulation of hormone secretion • positive regulation of blood vessel diameter • negative regulation of feeding behavior Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7349	22226
Ensembl	ENSG00000163794	ENSMUSG00000038676
UniProt	P55089	P81615
RefSeq (mRNA)	NM_003353	NM_021290 NM_001346010
RefSeq (protein)	NP_003344	NP_001332939 NP_067265
Location (UCSC)	Chr 2: 27.31 – 27.31 Mb	Chr 2: 31.14 – 31.14 Mb
PubMed search

2RMF, 3N96

7349

22226

ENSG00000163794

ENSMUSG00000038676

P55089

P81615

NM_003353

NM_021290
NM_001346010

NP_003344

NP_001332939
NP_067265

Urocortin is a protein that in humans is encoded by the UCN gene. Urocortin belongs to the corticotropin-releasing factor (CRF) family of proteins which includes CRF, urotensin I, sauvagine, urocortin II and urocortin III. Urocortin is involved in the mammalian stress response, and regulates aspects of appetite and stress response.

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