The band released a video for the song on February 11, 2016 that featured the members in a zero gravity environment created via flight in a reduced gravity aircraft. They produced the video with support from the Russian S7 Airlines.

The music video for "Upside Down & Inside Out" features the band moving about in zero gravity created by the parabolic flight path of a reduced gravity aircraft in concert with the song, performing various stunts otherwise impossible at normal gravity, including the use of props such as laptop computers and tablets, dozens of balls, and paint-filled balloons. Two trained aerialist acrobats, Tatyana Martynova and Anastasia Burdina, also perform during the video, acting as air hostesses from S7 Airlines, and performing various aerial acrobatics, including a demonstration of the conservation of angular momentum.

Band member Damian Kulash had the idea of doing a zero gravity video for some time, and was excited when commercial space travel efforts were started around 2007 with SpaceX and Virgin Galactic. He and his co-director sister Trish Sie, had been able to ride on the NASA "Vomit Comet" in November 2012, but at the time considered the possibilities of realizing a music video aboard one to be limiting. In June 2016, Russian ad agency, TutkovBudkov, conceived an idea of a partnership between the Russian S7 Airlines and OK Go that would have resulted in production of a music video aboard one of the airline's planes. The agency further organized a meeting between Kulash and S7 Airlines' representatives at the Cannes Lions International Festival of Creativity, the latter party agreeing to provide the band the funding and aircraft support to make their video. Additional support for the video production came from Good Morning America, Facebook, and Instagram. The use of "Upside Down & Inside Out" as the song for the video only came after they recognized the opportunity to create this video, rather than planning the video when creating the song. By happenstance, the song's lyrics are about "discombobulation", according to Kulash, and included the line "gravity's just a habit that you're pretty sure you can't break", making it a perfect fit for the video.

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Wikipedia