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The 2010 United States Senate election in Ohio was held on November 2, 2010, as one of many Ohio elections in 2010. Incumbent two-term Republican U.S. Senator George Voinovich decided to retire instead of seeking a third term. Republican Rob Portman won the open seat.
Congressman Tim Ryan, Secretary of State Jennifer Brunner, and Lieutenant Governor Lee Fisher were considered leading contenders to run against George Voinovich.Ohio Governor Ted Strickland urged Jennifer Brunner to run for re-election rather than run for the Senate.Cuyahoga County Commissioner Peter Lawson Jones and Ohio State Representative Tyrone Yates considered running, but both withdrew from consideration.
On February 17, 2009, Brunner and Fisher both officially announced their candidacies for the now-open seat election, with Strickland officially endorsing Fisher. Ryan declined to run and endorsed Fisher in July.
Fisher was endorsed by Governor Ted Strickland and U.S. Representatives John Boccieri, Tim Ryan, Zack Space, and Charlie Wilson.